TY - JOUR
T1 - Experimental eradication of pinworms (Syphacia obvelata and Aspiculuris tetraptera) from mice colonies using ivermectin
AU - Sueta, Teruko
AU - Miyoshi, Ichiro
AU - Okamura, Tadashi
AU - Kasai, Noriyuki
N1 - Copyright:
Copyright 2005 Elsevier B.V., All rights reserved.
PY - 2002/7
Y1 - 2002/7
N2 - A spray administration of ivermectin was evaluated for the treatment of pinworm infection in mice. In this study, a spray of 0.1% ivermectin injectable solution over the entire cage once a week, for three consecutive weeks (one cycle treatment), was effective in eradicating both Syphacia obvelata and Aspiculuris tetraptera from mice under experimental conditions. In addition, no acute toxicity was observed in 105 mothers or 687 neonates treated with ivermectin, indicating that ivermectin does not affect murine reproduction. Finally, we attempted to eradicate pinworms from infected mice in our institute using this method. Two cycles of treatment were administered, with a two-week pause between cycles, resulting in complete eradication for at least one year. Treating mouse colonies with spray ivermectin is inexpensive, safe, requires very little labor and is very effective at eradicating pinworms from mice.
AB - A spray administration of ivermectin was evaluated for the treatment of pinworm infection in mice. In this study, a spray of 0.1% ivermectin injectable solution over the entire cage once a week, for three consecutive weeks (one cycle treatment), was effective in eradicating both Syphacia obvelata and Aspiculuris tetraptera from mice under experimental conditions. In addition, no acute toxicity was observed in 105 mothers or 687 neonates treated with ivermectin, indicating that ivermectin does not affect murine reproduction. Finally, we attempted to eradicate pinworms from infected mice in our institute using this method. Two cycles of treatment were administered, with a two-week pause between cycles, resulting in complete eradication for at least one year. Treating mouse colonies with spray ivermectin is inexpensive, safe, requires very little labor and is very effective at eradicating pinworms from mice.
KW - Aspiculuris tetraptera
KW - Ivermectin
KW - Mouse
KW - Syphacia obvelata
UR - http://www.scopus.com/inward/record.url?scp=0036653667&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036653667&partnerID=8YFLogxK
U2 - 10.1538/expanim.51.367
DO - 10.1538/expanim.51.367
M3 - Article
C2 - 12221930
AN - SCOPUS:0036653667
VL - 51
SP - 367
EP - 373
JO - Experimental Animals
JF - Experimental Animals
SN - 1341-1357
IS - 4
ER -