Experimental eradication of pinworms (Syphacia obvelata and Aspiculuris tetraptera) from mice colonies using ivermectin

Teruko Sueta, Ichiro Miyoshi, Tadashi Okamura, Noriyuki Kasai

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

A spray administration of ivermectin was evaluated for the treatment of pinworm infection in mice. In this study, a spray of 0.1% ivermectin injectable solution over the entire cage once a week, for three consecutive weeks (one cycle treatment), was effective in eradicating both Syphacia obvelata and Aspiculuris tetraptera from mice under experimental conditions. In addition, no acute toxicity was observed in 105 mothers or 687 neonates treated with ivermectin, indicating that ivermectin does not affect murine reproduction. Finally, we attempted to eradicate pinworms from infected mice in our institute using this method. Two cycles of treatment were administered, with a two-week pause between cycles, resulting in complete eradication for at least one year. Treating mouse colonies with spray ivermectin is inexpensive, safe, requires very little labor and is very effective at eradicating pinworms from mice.

Original languageEnglish
Pages (from-to)367-373
Number of pages7
JournalExperimental Animals
Volume51
Issue number4
DOIs
Publication statusPublished - 2002 Jul

Keywords

  • Aspiculuris tetraptera
  • Ivermectin
  • Mouse
  • Syphacia obvelata

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

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