Experimental autoimmune thyroiditis in nonobese diabetic mice lacking interferon regulatory factor-1

Zhongtian Jin, Kouki Mori, Keisei Fujimori, Saeko Hoshikawa, Jun Ichi Tani, Jo Satoh, Sadayoshi Ito, Susumu Satomi, Katsumi Yoshida

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Interferon regulatory factor-1 (IRF-1) is pivotal in the regulation of interferon (IFN)-mediated immune reactions, and studies suggest that IRF-1 is involved in the development of autoimmune diseases. IRF-1+/+, +/-, and -/- nonobese diabetic (NOD) mice were immunized with mouse thyroglobulin (mTg) to determine whether IRF-1 is required in experimental autoimmune thyroiditis (EAT), a murine model for Hashimoto's thyroiditis (HT). IRF-1-deficient mice developed EAT and anti-mTg antibodies comparable to IRF-1+/+ and +/- mice. Whereas both CD4+ and CD8+ T cells were found in thyroids of IRF-1+/+ mice, the latter was not in IRF-1-/- mice. Major histocompatibility complex class II antigen was comparably expressed in thyroids of IRF-1+/+ and -/- mice. Lack of IRF-1 resulted in decreased CD8+ T cell number in the spleen and reduced IFNγ production by splenocytes. Our results suggest that IRF-1 is not pivotal in EAT in NOD mice.

Original languageEnglish
Pages (from-to)187-192
Number of pages6
JournalClinical Immunology
Volume113
Issue number2
DOIs
Publication statusPublished - 2004 Nov

Keywords

  • IRF-1
  • NOD mice
  • Thyroiditis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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