Abstract
Interferon regulatory factor-1 (IRF-1) is pivotal in the regulation of interferon (IFN)-mediated immune reactions, and studies suggest that IRF-1 is involved in the development of autoimmune diseases. IRF-1+/+, +/-, and -/- nonobese diabetic (NOD) mice were immunized with mouse thyroglobulin (mTg) to determine whether IRF-1 is required in experimental autoimmune thyroiditis (EAT), a murine model for Hashimoto's thyroiditis (HT). IRF-1-deficient mice developed EAT and anti-mTg antibodies comparable to IRF-1+/+ and +/- mice. Whereas both CD4+ and CD8+ T cells were found in thyroids of IRF-1+/+ mice, the latter was not in IRF-1-/- mice. Major histocompatibility complex class II antigen was comparably expressed in thyroids of IRF-1+/+ and -/- mice. Lack of IRF-1 resulted in decreased CD8+ T cell number in the spleen and reduced IFNγ production by splenocytes. Our results suggest that IRF-1 is not pivotal in EAT in NOD mice.
Original language | English |
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Pages (from-to) | 187-192 |
Number of pages | 6 |
Journal | Clinical Immunology |
Volume | 113 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2004 Nov |
Externally published | Yes |
Keywords
- IRF-1
- NOD mice
- Thyroiditis
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology