Experimental animal models in Mongolian gerbils and mice

H. Isogai, E. Isogai, K. Yokota, K. Oguma

    Research output: Contribution to journalArticlepeer-review


    Helicobacter pylori is an emerging candidate agent for the genesis of chronic gastritis and peptic ulcer. There have been many challenges to establish an experimental infection with H. pylori in animals. In recent, several studies reported for animal infection with this organism. One of them was the study using urinary system. The study indicated the ability of H. pylori to induce inflammation without significant low pH condition. Experimental infection in Mongolian gerbils showed that H. pylori could colonize on the surface of the gastric mucosa in animals without human. The study of nude mice by Karita et al. showed several valuable facts concerning the relation between bacterial pathogenicity and potential of bacterial colonization in stomach. The study in which remaining of bacteria was extended showed that colonization of H. pylori was affected by bacterial flora in the stomach.

    Original languageEnglish
    Pages (from-to)3138-3143
    Number of pages6
    JournalNippon rinsho. Japanese journal of clinical medicine
    Issue number12
    Publication statusPublished - 1993 Dec

    ASJC Scopus subject areas

    • Medicine(all)


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