Exon/intron organization and transcription units of the human acyl-CoA synthetase 4 gene

Hiroyuki Minekura, Man Jong Kang, Yousuke Inagaki, Yong Yeon Cho, Hiroyuki Suzuki, Takahiro Fujino, Tokuo T. Yamamoto

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Acyl-CoA synthetase 4 (ACS4) is an arachidonate-preferring isozyme of ACS family predominantly expressed in steroidogenic tissues. Isolation and characterization of genomic clones encoding human ACS4 revealed that the genomic organization of the gene. The human ACS4 gene spans approximately 90 kb and consists of 16 exons. Sequence inspection of the 5′-flanking region revealed potential DNA elements including GATAs, p300, AP-4, SRY, CREB and MyoD. A minimal promoter region required for the expression of ACS4 in HeLa S3 cells was determined. The human ACS4 gene was mapped between the STS markers, WI-17685 and CHLC.GATA81B07 on Xq22-23 region.

Original languageEnglish
Pages (from-to)80-86
Number of pages7
JournalBiochemical and biophysical research communications
Volume286
Issue number1
DOIs
Publication statusPublished - 2001

Keywords

  • Acyl-CoA synthetase
  • Arachidonate
  • Fatty acid metabolism
  • Genomic organization

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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