Exogenous hypercholesterolemic rats, compared with their progenitor, Sprague-Dawley rats, promptly alter cholesterol metabolism in the liver and secrete cholesterol-rich particles in response to dietary cholesterol

Masanobu Sakono, Haruhiko Mori, Koji Nagao, Masao Sato, Ikuo Ikeda, Kyosuke Yamamoto, Katsumi Imaizumi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Early responses of cholesterol metabolism to dietary cholesterol were compared between exogenous hypercholesterolemic (ExHC) and Sprague-Dawley rats. Both strains had a similar radioactivity of [14C]cholesterol in the serum half a day after the oral administration, but thereafter the radioactivity disappeared slowly in ExHC rats. ExHC rats promptly altered in response to the dietary cholesterol, activities of cholesterol 7α-hydroxylase and cholesterol synthesis in the liver and fecal excretion of bile acids derived from [14C]cholesterol administered orally. Lymphatic transport for 24 hr of [14C]cholesterol was similar between the strains. Triton administration resulted in a marked accumulation of cholesterol in serum d > 1.006 g/ml lipoproteins in ExHC rats; in addition, the formation of cholesteryl esters from [14C]oleic acid intravenously infused was greater in ExHC rats. These results indicate that ExHC rats increase serum cholesterol in response to enous cholesterol by decreasing the liver uptake and enhancing the secretion in the liver.

Original languageEnglish
Pages (from-to)803-808
Number of pages6
JournalComparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
Volume113
Issue number4
DOIs
Publication statusPublished - 1996 Jan 1
Externally publishedYes

Keywords

  • 7α-hydroxylase
  • bile acids
  • cholesterol
  • cholesterol absorption
  • cholesterol synthesis
  • cholesterol uptake
  • cholesteryl esters
  • exogenous hypercholesterolemic
  • secretion of lipoprotein
  • triacylglycerols

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology

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