TY - JOUR
T1 - Exocytosis upon osmotic swelling in human epithelial cells
AU - Okada, Yasunobu
AU - Hazama, Akihiro
AU - Hashimoto, Akira
AU - Maruyama, Yoshio
AU - Kubo, Machiko
N1 - Funding Information:
The authors are grateful to Prof. E. Neher (G6ttin-gen), Prof, S.G. Schultz (Houston) and Prof. M. Kuno (Kyoto) for their reading of an earlier draft of the manuscript. Thanks are due to Dr. A.F. James for assistance in preparing the manuscript. This work was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan.
PY - 1992/6/11
Y1 - 1992/6/11
N2 - Upon osmotic swelling human epithelial cells exhibited significant increases in the membrane capacitance. Evidence for exocytosis includes its dependency on temperature, cytosolic Ca2+ and ATP as well as its sensitivity to guanosine 5′-O-(3-thio)triphosphate (GTPγS) and N-ethylmaleimide (NEM). A role of the osmotic exocytosis in the subsequent cell volume regulation is suggested.
AB - Upon osmotic swelling human epithelial cells exhibited significant increases in the membrane capacitance. Evidence for exocytosis includes its dependency on temperature, cytosolic Ca2+ and ATP as well as its sensitivity to guanosine 5′-O-(3-thio)triphosphate (GTPγS) and N-ethylmaleimide (NEM). A role of the osmotic exocytosis in the subsequent cell volume regulation is suggested.
KW - Cell volume regulation
KW - Exocytosis
KW - Osmotic swelling
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U2 - 10.1016/0005-2736(92)90348-P
DO - 10.1016/0005-2736(92)90348-P
M3 - Article
C2 - 1616921
AN - SCOPUS:0026651360
VL - 1107
SP - 201
EP - 205
JO - Biochimica et Biophysica Acta - Biomembranes
JF - Biochimica et Biophysica Acta - Biomembranes
SN - 0005-2736
IS - 1
ER -