Exocytosis upon osmotic swelling in human epithelial cells

Yasunobu Okada, Akihiro Hazama, Akira Hashimoto, Yoshio Maruyama, Machiko Kubo

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


Upon osmotic swelling human epithelial cells exhibited significant increases in the membrane capacitance. Evidence for exocytosis includes its dependency on temperature, cytosolic Ca2+ and ATP as well as its sensitivity to guanosine 5′-O-(3-thio)triphosphate (GTPγS) and N-ethylmaleimide (NEM). A role of the osmotic exocytosis in the subsequent cell volume regulation is suggested.

Original languageEnglish
Pages (from-to)201-205
Number of pages5
JournalBBA - Biomembranes
Issue number1
Publication statusPublished - 1992 Jun 11
Externally publishedYes


  • Cell volume regulation
  • Exocytosis
  • Osmotic swelling

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology


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