Existence of tartaric acid-resistant acid phosphatase in adult T cell leukemia and B-CLL and its significance

T. Usui; T. Ohkubo; K. Kita; H. Konishi; T. Hattori; N. Uehara; H. Sawada; H. Uchino

Existence of tartaric acid-resistant acid phosphatase in adult T cell leukemia and B-CLL and its significance

T. Usui, T. Ohkubo, K. Kita, H. Konishi, T. Hattori, N. Uehara, H. Sawada, H. Uchino

International Research Institute of Disaster Science (IRIDeS)

Research output: Contribution to journal › Article

Abstract

Acid phosphatase isozyme patterns in normal peripheral lymphocytes and various lymphoid leukemia cells were examined by polyacrylamide gel electrophoresis. Five fractions (F-I, F-II, F-III, F-IV, F-V) were separated by this method. F-V activity was different from the others in its resistance to L(+)-tartaric acid treatment. It was generally accepted that F-V was characteristic of hairy cell leukemia; however, our results revealed that F-V existed not only in hairy cell leukemia cells but also in adult T-cell leukemia cells, B-CLL cells, and normal T-enriched and T-depleted cell populations. F-V existed neither in null-ALL, T-ALL nor in B-ALL, which might deviate from immature lymphocytes. From the above results, we suggest that tartaric acid-resistant acid phosphatase activity (F-V) may be one of the markers of the differentiation of lymphocytes.

Original language	English
Pages (from-to)	593-596
Number of pages	4
Journal	Acta Haematologica Japonica
Volume	43
Issue number	3
Publication status	Published - 1980 Dec 1

ASJC Scopus subject areas

Hematology

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Usui, T., Ohkubo, T., Kita, K., Konishi, H., Hattori, T., Uehara, N., Sawada, H., & Uchino, H. (1980). Existence of tartaric acid-resistant acid phosphatase in adult T cell leukemia and B-CLL and its significance. Acta Haematologica Japonica, 43(3), 593-596.

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abstract = "Acid phosphatase isozyme patterns in normal peripheral lymphocytes and various lymphoid leukemia cells were examined by polyacrylamide gel electrophoresis. Five fractions (F-I, F-II, F-III, F-IV, F-V) were separated by this method. F-V activity was different from the others in its resistance to L(+)-tartaric acid treatment. It was generally accepted that F-V was characteristic of hairy cell leukemia; however, our results revealed that F-V existed not only in hairy cell leukemia cells but also in adult T-cell leukemia cells, B-CLL cells, and normal T-enriched and T-depleted cell populations. F-V existed neither in null-ALL, T-ALL nor in B-ALL, which might deviate from immature lymphocytes. From the above results, we suggest that tartaric acid-resistant acid phosphatase activity (F-V) may be one of the markers of the differentiation of lymphocytes.",

author = "T. Usui and T. Ohkubo and K. Kita and H. Konishi and T. Hattori and N. Uehara and H. Sawada and H. Uchino",

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T1 - Existence of tartaric acid-resistant acid phosphatase in adult T cell leukemia and B-CLL and its significance

AU - Usui, T.

AU - Ohkubo, T.

AU - Kita, K.

AU - Konishi, H.

AU - Hattori, T.

AU - Uehara, N.

AU - Sawada, H.

AU - Uchino, H.

PY - 1980/12/1

Y1 - 1980/12/1

N2 - Acid phosphatase isozyme patterns in normal peripheral lymphocytes and various lymphoid leukemia cells were examined by polyacrylamide gel electrophoresis. Five fractions (F-I, F-II, F-III, F-IV, F-V) were separated by this method. F-V activity was different from the others in its resistance to L(+)-tartaric acid treatment. It was generally accepted that F-V was characteristic of hairy cell leukemia; however, our results revealed that F-V existed not only in hairy cell leukemia cells but also in adult T-cell leukemia cells, B-CLL cells, and normal T-enriched and T-depleted cell populations. F-V existed neither in null-ALL, T-ALL nor in B-ALL, which might deviate from immature lymphocytes. From the above results, we suggest that tartaric acid-resistant acid phosphatase activity (F-V) may be one of the markers of the differentiation of lymphocytes.

AB - Acid phosphatase isozyme patterns in normal peripheral lymphocytes and various lymphoid leukemia cells were examined by polyacrylamide gel electrophoresis. Five fractions (F-I, F-II, F-III, F-IV, F-V) were separated by this method. F-V activity was different from the others in its resistance to L(+)-tartaric acid treatment. It was generally accepted that F-V was characteristic of hairy cell leukemia; however, our results revealed that F-V existed not only in hairy cell leukemia cells but also in adult T-cell leukemia cells, B-CLL cells, and normal T-enriched and T-depleted cell populations. F-V existed neither in null-ALL, T-ALL nor in B-ALL, which might deviate from immature lymphocytes. From the above results, we suggest that tartaric acid-resistant acid phosphatase activity (F-V) may be one of the markers of the differentiation of lymphocytes.

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