Exercise- And drug dose-dependent metabolic assay device using the hydrogel-supported skeletal muscle cells

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have prepared contractile skeletal muscle cellular micropatterns supported by the hydrogel to investigate the relationship between exercise or drug administration and development of type 2 diabetes under controlled culture conditions. The muscle cell-patterned gel sheet can be handled easily while sustaining the cellular structure and activity, allowing for the first time to be combined with the various analytical devices on demand. In this study, two types of bioassay devices were constructed by combining the gel sheet with our original microelectrode-printed flexible gel sheet for electrically inducible exercise-dependent metabolic assay, and with a microfluidics for drug screening.

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages383-385
Number of pages3
ISBN (Print)9780979806452
Publication statusPublished - 2012 Jan 1
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: 2012 Oct 282012 Nov 1

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Other

Other16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
CountryJapan
CityOkinawa
Period12/10/2812/11/1

Keywords

  • Hydrogel
  • Microfluidics
  • Skeletal muscle cell

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Nagamine, K., Kaji, H., Kanzaki, M., & Nishizawa, M. (2012). Exercise- And drug dose-dependent metabolic assay device using the hydrogel-supported skeletal muscle cells. In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 (pp. 383-385). (Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012). Chemical and Biological Microsystems Society.