Excitotoxic lesions of histaminergic neurons by excitatory amino acid agonists in the rat brain

Kazuhiko Yanai, Xiao Lan Zhao, Takehiko Watanabe

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Excitotoxic lesions of histaminergic (HA) neurons in the rat hypothalamus were observed by the injection of ibotenate and N-methyl-D- aspartate (NMDA) while kainate, quisqualate and quinolinate had no significant effects on HA neurons. An NMDA selective antagonist, 2-amino-5- phosphonopentanoic acid, was able to block the toxic effects of both NMDA and ibotenate almost completely, but kynurenate was a weaker inhibitor of ibotenate or NMDA-induced neurotoxicity. These results suggest that there exists an ibotenate-sensitive and quinolinate-insensitive NMDA receptor subtype on HA neurons.

Original languageEnglish
Pages (from-to)159-162
Number of pages4
JournalNeuroscience Letters
Volume232
Issue number3
DOIs
Publication statusPublished - 1997 Sep 5

Keywords

  • Histaminergic neurons
  • Hypothalamus
  • Ibotenate
  • Lesions
  • N-Methyl-D- aspartate
  • Quinolinate
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Excitotoxic lesions of histaminergic neurons by excitatory amino acid agonists in the rat brain'. Together they form a unique fingerprint.

  • Cite this