Excitation of autonomic nerves by 4-aminopyridine in the isolated, blood-perfused sino-atrial node preparation of the dog

Teruyuki Yanagisawa, Keisuke Satoh, Norio Taira

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

4-Aminopyridine injected into the sinus node artery produced a long-lasting decrease in sinus rate preceded by a transient increase. With a large dose, a long-lasting increase in sinus rate was superimposed on the long-lasting decrease phase. The long-lasting decrease and increase in sinus rate were abolished by 1-hyoscyamine and propranolol respectively, and both were reduced by tetrodotoxin. These results can be interpreted as being due to excitation of autonomic nerves by 4-aminopyridine.

Original languageEnglish
Pages (from-to)189-192
Number of pages4
JournalEuropean Journal of Pharmacology
Volume49
Issue number2
DOIs
Publication statusPublished - 1978 May 15

Keywords

  • 4-Aminopyridine
  • Nerve excitation
  • Parasympathetic nerves
  • Sino-atrial node
  • Sympathetic nerves
  • Tetrodotoxin

ASJC Scopus subject areas

  • Pharmacology

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