Exaggerated Response of Renin Secretion to Captopril (Sq 14225) in Renovascular Hypertension

Yutaka Imai, Keishi Abe, Yoichi Otsuka, Yutaka Sakurai, Toru Ito, Makito Sato, Toshiaki Haruyama, Ken Omata, Masao Hiwatari

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Captopril (SQ 14225), an orally active converting enzyme inhibitor, was administered in a dose of 50mg to 12 normotensive subjects (Group I), 26 essential hypertensive patients (Group II), and 8 renovascular hypertensive patients (Group III). In Group III, 5 of the 8 patients had control plasma renin activity (PRA) similar to those in Groups I and II patients, but the PRA response to the administration of captopril was greater in 7 of the 8 patients than those in Groups I and II. These 7 patients had either bilateral or unilateral main renal artery stenosis. Captopril caused no increase in PRA in the remaining 1 who had unilateral renal artery stenosis with contralateral renal aplasia. It is concluded that this provocation test is useful as a screening procedure for the diagnosis of renovascular hypertension.

Original languageEnglish
Pages (from-to)793-802
Number of pages10
JournalJapanese Heart Journal
Volume21
Issue number6
DOIs
Publication statusPublished - 1980

Keywords

  • Angiotensin I converting enzyme inhibitor
  • Cardiovascular response
  • Essential hypertension
  • Screening test

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Exaggerated Response of Renin Secretion to Captopril (Sq 14225) in Renovascular Hypertension'. Together they form a unique fingerprint.

Cite this