Evolutionary dynamics of spliceosomal intron revealed by in silico analyses of the P-Type ATPase superfamily genes

Toshiyuki Oda, Ryosuke L. Ohniwa, Yuki Suzuki, Masatsugu Denawa, Masahiro Kumeta, Hideyuki Okamura, Kunio Takeyasu

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

It has been long debated whether spliceosomal introns originated in the common ancestor of eukaryotes and prokaryotes. In this study, we tested the possibility that extant introns were inherited from the common ancestor of eukaryotes and prokaryotes using in silico simulation. We first identified 21 intron positions that are shared among different families of the P-Type ATPase superfamily, some of which are known to have diverged before the separation of prokaryotes and eukaryotes. Theoretical estimates of the expected number of intron positions shared by different genes suggest that the introns at those 21 positions were inserted independently. There seems to be no intron that arose from before the diversification of the P-Type ATPase superfamily. Namely, the present introns were inserted after the separation of eukaryotes and prokaryotes.

Original languageEnglish
Pages (from-to)2285-2293
Number of pages9
JournalMolecular Biology Reports
Volume38
Issue number4
DOIs
Publication statusPublished - 2011 Apr
Externally publishedYes

Keywords

  • Introns-early theory
  • Introns-late theory
  • P-Type ATPase
  • Proto-splice site
  • Simulation
  • Spliceosomal intron

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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