TY - JOUR
T1 - Evolutionary developmental biology and genomics
AU - Cãestro, Cristian
AU - Yokoi, Hayato
AU - Postlethwait, John H.
N1 - Funding Information:
We thank for support R01 RR020833, and P01 HD22486 from the National Institutes of Health, and IOB-0719577, from the US National Science Foundation.
PY - 2007/12
Y1 - 2007/12
N2 - Reciprocal questions often frame studies of the evolution of developmental mechanisms. How can species share similar developmental genetic toolkits but still generate diverse life forms? Conversely, how can similar forms develop from different toolkits? Genomics bridges the gap between evolutionary and developmental biology, and can help answer these evo-devo questions in several ways. First, it informs us about historical relationships, thus orienting the direction of evolutionary diversification. Second, genomics lists all toolkit components, thereby revealing contraction and expansion of the genome and suggesting mechanisms for evolution of both developmental functions and genome architecture. Finally, comparative genomics helps us to identify conserved non-coding elements and their relationship to genome architecture and development.
AB - Reciprocal questions often frame studies of the evolution of developmental mechanisms. How can species share similar developmental genetic toolkits but still generate diverse life forms? Conversely, how can similar forms develop from different toolkits? Genomics bridges the gap between evolutionary and developmental biology, and can help answer these evo-devo questions in several ways. First, it informs us about historical relationships, thus orienting the direction of evolutionary diversification. Second, genomics lists all toolkit components, thereby revealing contraction and expansion of the genome and suggesting mechanisms for evolution of both developmental functions and genome architecture. Finally, comparative genomics helps us to identify conserved non-coding elements and their relationship to genome architecture and development.
UR - http://www.scopus.com/inward/record.url?scp=36248946042&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36248946042&partnerID=8YFLogxK
U2 - 10.1038/nrg2226
DO - 10.1038/nrg2226
M3 - Review article
C2 - 18007650
AN - SCOPUS:36248946042
VL - 8
SP - 932
EP - 942
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
SN - 1471-0056
IS - 12
ER -