Evolutionary developmental biology and genomics

Cristian Cãestro, Hayato Yokoi, John H. Postlethwait

Research output: Contribution to journalReview articlepeer-review

97 Citations (Scopus)


Reciprocal questions often frame studies of the evolution of developmental mechanisms. How can species share similar developmental genetic toolkits but still generate diverse life forms? Conversely, how can similar forms develop from different toolkits? Genomics bridges the gap between evolutionary and developmental biology, and can help answer these evo-devo questions in several ways. First, it informs us about historical relationships, thus orienting the direction of evolutionary diversification. Second, genomics lists all toolkit components, thereby revealing contraction and expansion of the genome and suggesting mechanisms for evolution of both developmental functions and genome architecture. Finally, comparative genomics helps us to identify conserved non-coding elements and their relationship to genome architecture and development.

Original languageEnglish
Pages (from-to)932-942
Number of pages11
JournalNature Reviews Genetics
Issue number12
Publication statusPublished - 2007 Dec
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)


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