Evolution of the apolipoprotein E receptor 2 gene by exon loss

Hyoun Ju Kim, Dong Ho Kim, Kenta Magoori, Shigeru Saeki, Tokuo T. Yamamoto

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

The apolipoprotein E receptor 2 (apoER2) gene consists of a mosaic of exons, which may have been assembled by 'exon shuffling.' Analysis of apoER2 transcripts in several species reveals a lost repeat in the ligand-binding domain of primate apoER2. A pseudo-exon found in the primate apoER2 genes corresponds to the lost repeat but contains a crucial deletion that leads to a translational frameshift. The pseudo-exon sequence in primary transcripts of the human apoER2 gene is shown to be abolished by exon skipping due to two nucleotide substitutions at the 5'-splice donor adjacent to the pseudo-exon. These data suggest the occurrence of exon loss in the evolution of the primate apoER2 gene.

Original languageEnglish
Pages (from-to)451-456
Number of pages6
JournalJournal of biochemistry
Volume124
Issue number2
DOIs
Publication statusPublished - 1998 Aug

Keywords

  • Exon shuffling
  • Exon skipping
  • Pseudo exon
  • Repetitive sequence
  • apoE receptor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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