Evidence of a direct cellular protective effect of Rho-kinase inhibitors on endothelin-induced cardiac myocyte hypertrophy

Shin ichi Satoh, Koh Kawasaki, Ichiro Ikegaki, Toshio Asano, Hiroaki Shimokawa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Using a cellular approach, the present study examined whether fasudil and active metabolite hydroxyfasudil, Rho-kinase inhibitors, exert a direct protective effect on endothelin-induced cardiac myocyte hypertrophy in vitro. Treatment with endothelin (10. nM) caused significant hypertrophy of cultured neonatal rat cardiomyocytes by a 21.2% increase in cell surface area. Fasudil (1-10. μM) and hydroxyfasudil (0.3-10. μM) significantly prevented endothelin-induced cardiomyocyte hypertrophy. The present results suggest that inhibition of cardiac hypertrophy by fasudil is, at least in part, due to direct protection of cardiomyocytes from hypertrophy.

Original languageEnglish
Pages (from-to)338-340
Number of pages3
JournalBiochemical and biophysical research communications
Volume424
Issue number2
DOIs
Publication statusPublished - 2012 Jul 27

Keywords

  • Cardiomyocyte hypertrophy
  • Fasudil
  • Rho-kinase

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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