Evidence for two distinct voltage-gated calcium channel currents in bovine adrenal glomerulosa cells

Hiroshi Matsunaga; Naohida Yamashita; Yoshio Maruyama; Itaru Kojima; Kiyoshi Kurokawa

doi:10.1016/0006-291X(87)90514-6

Evidence for two distinct voltage-gated calcium channel currents in bovine adrenal glomerulosa cells

Hiroshi Matsunaga, Naohida Yamashita, Yoshio Maruyama, Itaru Kojima, Kiyoshi Kurokawa

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

We analyzed inward Ca²⁺ currents in single bovine adrenal glomerulosa cell using whole-cell patch clamp techniques. Two types of voltage-gated Ca²⁺ channel currents were identified. One was a transient (T) type which decayed within 100 ms, characterized by a low threshold voltage (about -70 mv) similar to that seen in rat adrenal glomerulosa cells (Matsunaga, H. et al. (1987) Pflügers Arch. 408, 351-355.) Another was a long-lasting (L) type which shows a more positive threshold potential. The present results suggest that while T type Ca²⁺ channels may explain initial calcium influx in response to an elevation in extracellular K⁺, L type Ca²⁺ channels may allow sustained calcium influx which is necessary for sustained aldosterone secretion.

Original language	English
Pages (from-to)	1049-1054
Number of pages	6
Journal	Biochemical and biophysical research communications
Volume	149
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(87)90514-6
Publication status	Published - 1987 Dec 31

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "Evidence for two distinct voltage-gated calcium channel currents in bovine adrenal glomerulosa cells",

abstract = "We analyzed inward Ca2+ currents in single bovine adrenal glomerulosa cell using whole-cell patch clamp techniques. Two types of voltage-gated Ca2+ channel currents were identified. One was a transient (T) type which decayed within 100 ms, characterized by a low threshold voltage (about -70 mv) similar to that seen in rat adrenal glomerulosa cells (Matsunaga, H. et al. (1987) Pfl{\"u}gers Arch. 408, 351-355.) Another was a long-lasting (L) type which shows a more positive threshold potential. The present results suggest that while T type Ca2+ channels may explain initial calcium influx in response to an elevation in extracellular K+, L type Ca2+ channels may allow sustained calcium influx which is necessary for sustained aldosterone secretion.",

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AU - Matsunaga, Hiroshi

AU - Yamashita, Naohida

AU - Maruyama, Yoshio

AU - Kojima, Itaru

AU - Kurokawa, Kiyoshi

PY - 1987/12/31

Y1 - 1987/12/31

N2 - We analyzed inward Ca2+ currents in single bovine adrenal glomerulosa cell using whole-cell patch clamp techniques. Two types of voltage-gated Ca2+ channel currents were identified. One was a transient (T) type which decayed within 100 ms, characterized by a low threshold voltage (about -70 mv) similar to that seen in rat adrenal glomerulosa cells (Matsunaga, H. et al. (1987) Pflügers Arch. 408, 351-355.) Another was a long-lasting (L) type which shows a more positive threshold potential. The present results suggest that while T type Ca2+ channels may explain initial calcium influx in response to an elevation in extracellular K+, L type Ca2+ channels may allow sustained calcium influx which is necessary for sustained aldosterone secretion.

AB - We analyzed inward Ca2+ currents in single bovine adrenal glomerulosa cell using whole-cell patch clamp techniques. Two types of voltage-gated Ca2+ channel currents were identified. One was a transient (T) type which decayed within 100 ms, characterized by a low threshold voltage (about -70 mv) similar to that seen in rat adrenal glomerulosa cells (Matsunaga, H. et al. (1987) Pflügers Arch. 408, 351-355.) Another was a long-lasting (L) type which shows a more positive threshold potential. The present results suggest that while T type Ca2+ channels may explain initial calcium influx in response to an elevation in extracellular K+, L type Ca2+ channels may allow sustained calcium influx which is necessary for sustained aldosterone secretion.

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Evidence for two distinct voltage-gated calcium channel currents in bovine adrenal glomerulosa cells

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