Evidence for two distinct voltage-gated calcium channel currents in bovine adrenal glomerulosa cells

Hiroshi Matsunaga, Naohida Yamashita, Yoshio Maruyama, Itaru Kojima, Kiyoshi Kurokawa

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

We analyzed inward Ca2+ currents in single bovine adrenal glomerulosa cell using whole-cell patch clamp techniques. Two types of voltage-gated Ca2+ channel currents were identified. One was a transient (T) type which decayed within 100 ms, characterized by a low threshold voltage (about -70 mv) similar to that seen in rat adrenal glomerulosa cells (Matsunaga, H. et al. (1987) Pflügers Arch. 408, 351-355.) Another was a long-lasting (L) type which shows a more positive threshold potential. The present results suggest that while T type Ca2+ channels may explain initial calcium influx in response to an elevation in extracellular K+, L type Ca2+ channels may allow sustained calcium influx which is necessary for sustained aldosterone secretion.

Original languageEnglish
Pages (from-to)1049-1054
Number of pages6
JournalBiochemical and biophysical research communications
Volume149
Issue number3
DOIs
Publication statusPublished - 1987 Dec 31

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Evidence for two distinct voltage-gated calcium channel currents in bovine adrenal glomerulosa cells'. Together they form a unique fingerprint.

Cite this