Evidence for the involvement of Lfc and Tctex-1 in axon formation

Cecilia Conde, Cristina Arias, Maria Robin, Aiqun Li, Masaki Saito, Jen Zen Chuang, Angus C. Nairn, Ching Hwa Sung, Alfredo Cáceres

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

RhoA and Rac play key and opposite roles during neuronal polarization. We now show that Lfc, a guanosine nucleotide exchange factor (GEF), localizes to the Golgi apparatus and growth cones of developing neurons and negatively regulates neurite sprouting and axon formation through a Rho signaling pathway. Tctex-1, a dynein light chain implicated in axon outgrowth by modulating actin dynamics and Rac activity, colocalizes and physically interacts with Lfc, thus inhibiting its GEF activity, decreasing Rho-GTP levels, and functionally antagonizing Lfc during neurite formation.

Original languageEnglish
Pages (from-to)6793-6800
Number of pages8
JournalJournal of Neuroscience
Volume30
Issue number19
DOIs
Publication statusPublished - 2010 May 12
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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