Evidence for the interleukin-2 dependent expansion of leukemic cells in adult T cell leukemia

M. Maeda, N. Arima, Y. Daitoku, M. Kashihara, H. Okamoto, T. Uchiyama, K. Shirono, M. Matsuoka, T. Hattori, K. Takatsuki, K. Ikuta, A. Shimizu, T. Honjo, J. Yodoi

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65 Citations (Scopus)

Abstract

Interleukin 2 (IL-2) receptor/Tac antigen is abnormally expressed on cells of patients with adult T cell leukemia (ATL) caused by infection with human T lymphotropic virus type I (HTLV-I). Twenty-five patients with ATL were examined to determine whether their leukemic cells continued to show IL-2-dependent proliferation. In 21 patients, the in vitro proliferation of HTLV-I-infected nonleukemic T cell clones was found to be dependent on IL-2. However, clonality analysis based on T cell receptor gene rearrangement profiles and the site of HTLV-I provirus integration revealed IL-2-dependent growth in leukemic cells in four patients with ATL. These results provide evidence for the IL-2-dependent proliferation of leukemic cells in some ATL patients.

Original languageEnglish
Pages (from-to)1407-1411
Number of pages5
JournalBlood
Volume70
Issue number5
DOIs
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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