Abstract
Interleukin 2 (IL-2) receptor/Tac antigen is abnormally expressed on cells of patients with adult T cell leukemia (ATL) caused by infection with human T lymphotropic virus type I (HTLV-I). Twenty-five patients with ATL were examined to determine whether their leukemic cells continued to show IL-2-dependent proliferation. In 21 patients, the in vitro proliferation of HTLV-I-infected nonleukemic T cell clones was found to be dependent on IL-2. However, clonality analysis based on T cell receptor gene rearrangement profiles and the site of HTLV-I provirus integration revealed IL-2-dependent growth in leukemic cells in four patients with ATL. These results provide evidence for the IL-2-dependent proliferation of leukemic cells in some ATL patients.
Original language | English |
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Pages (from-to) | 1407-1411 |
Number of pages | 5 |
Journal | Blood |
Volume | 70 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1987 |
ASJC Scopus subject areas
- Biochemistry
- Immunology
- Hematology
- Cell Biology