Evidence for the interleukin-2 dependent expansion of leukemic cells in adult T cell leukemia

M. Maeda; N. Arima; Y. Daitoku; M. Kashihara; H. Okamoto; T. Uchiyama; K. Shirono; M. Matsuoka; T. Hattori; K. Takatsuki; K. Ikuta; A. Shimizu; T. Honjo; J. Yodoi

doi:10.1182/blood.v70.5.1407.1407

Evidence for the interleukin-2 dependent expansion of leukemic cells in adult T cell leukemia

M. Maeda, N. Arima, Y. Daitoku, M. Kashihara, H. Okamoto, T. Uchiyama, K. Shirono, M. Matsuoka, T. Hattori, K. Takatsuki, K. Ikuta, A. Shimizu, T. Honjo, J. Yodoi

International Research Institute of Disaster Science (IRIDeS)

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

Interleukin 2 (IL-2) receptor/Tac antigen is abnormally expressed on cells of patients with adult T cell leukemia (ATL) caused by infection with human T lymphotropic virus type I (HTLV-I). Twenty-five patients with ATL were examined to determine whether their leukemic cells continued to show IL-2-dependent proliferation. In 21 patients, the in vitro proliferation of HTLV-I-infected nonleukemic T cell clones was found to be dependent on IL-2. However, clonality analysis based on T cell receptor gene rearrangement profiles and the site of HTLV-I provirus integration revealed IL-2-dependent growth in leukemic cells in four patients with ATL. These results provide evidence for the IL-2-dependent proliferation of leukemic cells in some ATL patients.

Original language	English
Pages (from-to)	1407-1411
Number of pages	5
Journal	Blood
Volume	70
Issue number	5
DOIs	https://doi.org/10.1182/blood.v70.5.1407.1407
Publication status	Published - 1987

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

Access to Document

10.1182/blood.v70.5.1407.1407

Cite this

@article{017169d28b3742f385b00c3739b7eac5,

title = "Evidence for the interleukin-2 dependent expansion of leukemic cells in adult T cell leukemia",

abstract = "Interleukin 2 (IL-2) receptor/Tac antigen is abnormally expressed on cells of patients with adult T cell leukemia (ATL) caused by infection with human T lymphotropic virus type I (HTLV-I). Twenty-five patients with ATL were examined to determine whether their leukemic cells continued to show IL-2-dependent proliferation. In 21 patients, the in vitro proliferation of HTLV-I-infected nonleukemic T cell clones was found to be dependent on IL-2. However, clonality analysis based on T cell receptor gene rearrangement profiles and the site of HTLV-I provirus integration revealed IL-2-dependent growth in leukemic cells in four patients with ATL. These results provide evidence for the IL-2-dependent proliferation of leukemic cells in some ATL patients.",

author = "M. Maeda and N. Arima and Y. Daitoku and M. Kashihara and H. Okamoto and T. Uchiyama and K. Shirono and M. Matsuoka and T. Hattori and K. Takatsuki and K. Ikuta and A. Shimizu and T. Honjo and J. Yodoi",

year = "1987",

doi = "10.1182/blood.v70.5.1407.1407",

language = "English",

volume = "70",

pages = "1407--1411",

journal = "Blood",

issn = "0006-4971",

publisher = "American Society of Hematology",

number = "5",

}

TY - JOUR

T1 - Evidence for the interleukin-2 dependent expansion of leukemic cells in adult T cell leukemia

AU - Maeda, M.

AU - Arima, N.

AU - Daitoku, Y.

AU - Kashihara, M.

AU - Okamoto, H.

AU - Uchiyama, T.

AU - Shirono, K.

AU - Matsuoka, M.

AU - Hattori, T.

AU - Takatsuki, K.

AU - Ikuta, K.

AU - Shimizu, A.

AU - Honjo, T.

AU - Yodoi, J.

PY - 1987

Y1 - 1987

N2 - Interleukin 2 (IL-2) receptor/Tac antigen is abnormally expressed on cells of patients with adult T cell leukemia (ATL) caused by infection with human T lymphotropic virus type I (HTLV-I). Twenty-five patients with ATL were examined to determine whether their leukemic cells continued to show IL-2-dependent proliferation. In 21 patients, the in vitro proliferation of HTLV-I-infected nonleukemic T cell clones was found to be dependent on IL-2. However, clonality analysis based on T cell receptor gene rearrangement profiles and the site of HTLV-I provirus integration revealed IL-2-dependent growth in leukemic cells in four patients with ATL. These results provide evidence for the IL-2-dependent proliferation of leukemic cells in some ATL patients.

AB - Interleukin 2 (IL-2) receptor/Tac antigen is abnormally expressed on cells of patients with adult T cell leukemia (ATL) caused by infection with human T lymphotropic virus type I (HTLV-I). Twenty-five patients with ATL were examined to determine whether their leukemic cells continued to show IL-2-dependent proliferation. In 21 patients, the in vitro proliferation of HTLV-I-infected nonleukemic T cell clones was found to be dependent on IL-2. However, clonality analysis based on T cell receptor gene rearrangement profiles and the site of HTLV-I provirus integration revealed IL-2-dependent growth in leukemic cells in four patients with ATL. These results provide evidence for the IL-2-dependent proliferation of leukemic cells in some ATL patients.

UR - http://www.scopus.com/inward/record.url?scp=0023597217&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023597217&partnerID=8YFLogxK

U2 - 10.1182/blood.v70.5.1407.1407

DO - 10.1182/blood.v70.5.1407.1407

M3 - Article

C2 - 2889484

AN - SCOPUS:0023597217

VL - 70

SP - 1407

EP - 1411

JO - Blood

JF - Blood

SN - 0006-4971

IS - 5

ER -

Evidence for the interleukin-2 dependent expansion of leukemic cells in adult T cell leukemia

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this