Evidence for the importance of conformational equilibria in Rh-diphosphine complexes for the enantioselection in Rh-catalyzed asymmetric hydrogenation

Hideyuki Tsuruta; Tsuneo Imamoto; Kentaro Yamaguchi; Ilya D. Gridnev

doi:10.1016/j.tetlet.2005.02.115

Evidence for the importance of conformational equilibria in Rh-diphosphine complexes for the enantioselection in Rh-catalyzed asymmetric hydrogenation

Hideyuki Tsuruta, Tsuneo Imamoto, Kentaro Yamaguchi, Ilya D. Gridnev

SCI - Chemistry

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The conformations of the chelate cycles in the X-ray structures of norbornadiene- and cyclooctadiene-rhodium complexes of (R,R)-1,2-bis[(o- methylphenyl)phenylphosphino]ethane are dramatically different. Nevertheless, they demonstrate the same sense of enantioselection in asymmetric hydrogenation of dehydroamino acids.

Original language	English
Pages (from-to)	2879-2882
Number of pages	4
Journal	Tetrahedron Letters
Volume	46
Issue number	16
DOIs	https://doi.org/10.1016/j.tetlet.2005.02.115
Publication status	Published - 2005 Apr 18

Keywords

Asymmetric hydrogenation
Chiral diphosphines
Chiral rhodium complexes
Sense of enantioselection

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2005.02.115

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abstract = "The conformations of the chelate cycles in the X-ray structures of norbornadiene- and cyclooctadiene-rhodium complexes of (R,R)-1,2-bis[(o- methylphenyl)phenylphosphino]ethane are dramatically different. Nevertheless, they demonstrate the same sense of enantioselection in asymmetric hydrogenation of dehydroamino acids.",

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AU - Tsuruta, Hideyuki

AU - Imamoto, Tsuneo

AU - Yamaguchi, Kentaro

AU - Gridnev, Ilya D.

PY - 2005/4/18

Y1 - 2005/4/18

N2 - The conformations of the chelate cycles in the X-ray structures of norbornadiene- and cyclooctadiene-rhodium complexes of (R,R)-1,2-bis[(o- methylphenyl)phenylphosphino]ethane are dramatically different. Nevertheless, they demonstrate the same sense of enantioselection in asymmetric hydrogenation of dehydroamino acids.

AB - The conformations of the chelate cycles in the X-ray structures of norbornadiene- and cyclooctadiene-rhodium complexes of (R,R)-1,2-bis[(o- methylphenyl)phenylphosphino]ethane are dramatically different. Nevertheless, they demonstrate the same sense of enantioselection in asymmetric hydrogenation of dehydroamino acids.

KW - Asymmetric hydrogenation

KW - Chiral diphosphines

KW - Chiral rhodium complexes

KW - Sense of enantioselection

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 16

ER -

Evidence for the importance of conformational equilibria in Rh-diphosphine complexes for the enantioselection in Rh-catalyzed asymmetric hydrogenation

Abstract

Keywords

ASJC Scopus subject areas

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