Evidence for the importance of conformational equilibria in Rh-diphosphine complexes for the enantioselection in Rh-catalyzed asymmetric hydrogenation

Hideyuki Tsuruta, Tsuneo Imamoto, Kentaro Yamaguchi, Ilya D. Gridnev

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The conformations of the chelate cycles in the X-ray structures of norbornadiene- and cyclooctadiene-rhodium complexes of (R,R)-1,2-bis[(o- methylphenyl)phenylphosphino]ethane are dramatically different. Nevertheless, they demonstrate the same sense of enantioselection in asymmetric hydrogenation of dehydroamino acids.

Original languageEnglish
Pages (from-to)2879-2882
Number of pages4
JournalTetrahedron Letters
Volume46
Issue number16
DOIs
Publication statusPublished - 2005 Apr 18

Keywords

  • Asymmetric hydrogenation
  • Chiral diphosphines
  • Chiral rhodium complexes
  • Sense of enantioselection

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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