Evidence for brain activation in patients with takotsubo cardiomyopathy

Hideaki Suzuki, Yasuharu Matsumoto, Tomohiro Kaneta, Koichiro Sugimura, Jun Takahashi, Yoshihiro Fukumoto, Shoki Takahashi, Hiroaki Shimokawa

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Background: It remains to be elucidated whether brain activity is altered in takotsubo cardiomyopathy. Methods and Results: We measured cerebral blood flow (CBF) in 3 consecutive patients with takotsubo cardiomyopathy using 99 mTc ethyl cysteinate dimmer single photon-emission computed tomography (SPECT) in the acute and chronic phases. In all patients, CBF was significantly increased in the hippocampus, brainstem and basal ganglia and significantly decreased in the prefrontal cortex in the acute phase, which changes subsided in the chronic phase with full recovery of cardiac wall motion. Conclusions: These results provide the first direct evidence for brain activation in takotsubo cardiomyopathy.

Original languageEnglish
Pages (from-to)256-258
Number of pages3
JournalCirculation Journal
Volume78
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

Keywords

  • Brain
  • SPECT
  • Stress
  • Takotsubo cardiomyopathy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Suzuki, H., Matsumoto, Y., Kaneta, T., Sugimura, K., Takahashi, J., Fukumoto, Y., Takahashi, S., & Shimokawa, H. (2014). Evidence for brain activation in patients with takotsubo cardiomyopathy. Circulation Journal, 78(1), 256-258. https://doi.org/10.1253/circj.CJ-13-1276