Evaluation with MIB1 antibody of proliferative activity in ovarian clear cell adenocarcinoma

Yutaka Morimura; Kazuhiko Hoshi; Xiang Li Hang; Yoshimasa Takano; Mari Ohishi; Tsuyoshi Honda; Hidekazu Yamada; Akira Sato

doi:10.1097/00004347-199610000-00003

Evaluation with MIB1 antibody of proliferative activity in ovarian clear cell adenocarcinoma

Yutaka Morimura, Kazuhiko Hoshi, Xiang Li Hang, Yoshimasa Takano, Mari Ohishi, Tsuyoshi Honda, Hidekazu Yamada, Akira Sato

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

The purpose of this study was to determine whether proliferative activity is a prognostic factor in ovarian clear cell adenocarcinoma. The paraffin-embedded sections from eight cases of ovarian clear cell adenocarcinoma were immunostained with monoclonal antibody MIB1 using microwave oven heating for antigen retrieval. The difference in survival (Kaplan-Meier) between patients with high and low MIB1 expression was estimated with the generalized Wilcoxon test. MIB1 positivity ranged from 1.80 to 27.12% with a mean of 11.43%. A cutoff point of 10% dichotomized patients into two groups. The survival of high (≤10%) expressing tumors was worse than that of low (<10%) expressing tumors (p < 0.05). MIB1 immunostaining may have useful prognostic value in ovarian clear cell adenocarcinoma.

Original language	English
Pages (from-to)	315-319
Number of pages	5
Journal	International Journal of Gynecological Pathology
Volume	15
Issue number	4
DOIs	https://doi.org/10.1097/00004347-199610000-00003
Publication status	Published - 1996 Jan 1

Keywords

Clear cell adenocarcinoma
Immunohistochemistry
MIB1
Ovary
Prognosis

ASJC Scopus subject areas

Pathology and Forensic Medicine
Obstetrics and Gynaecology

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Morimura, Y., Hoshi, K., Hang, X. L., Takano, Y., Ohishi, M., Honda, T., Yamada, H., & Sato, A. (1996). Evaluation with MIB1 antibody of proliferative activity in ovarian clear cell adenocarcinoma. International Journal of Gynecological Pathology, 15(4), 315-319. https://doi.org/10.1097/00004347-199610000-00003

Evaluation with MIB1 antibody of proliferative activity in ovarian clear cell adenocarcinoma. / Morimura, Yutaka; Hoshi, Kazuhiko; Hang, Xiang Li; Takano, Yoshimasa; Ohishi, Mari; Honda, Tsuyoshi; Yamada, Hidekazu; Sato, Akira.

In: International Journal of Gynecological Pathology, Vol. 15, No. 4, 01.01.1996, p. 315-319.

Research output: Contribution to journal › Article

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