Abstract
The purpose of this study was to determine whether proliferative activity is a prognostic factor in ovarian clear cell adenocarcinoma. The paraffin-embedded sections from eight cases of ovarian clear cell adenocarcinoma were immunostained with monoclonal antibody MIB1 using microwave oven heating for antigen retrieval. The difference in survival (Kaplan-Meier) between patients with high and low MIB1 expression was estimated with the generalized Wilcoxon test. MIB1 positivity ranged from 1.80 to 27.12% with a mean of 11.43%. A cutoff point of 10% dichotomized patients into two groups. The survival of high (≤10%) expressing tumors was worse than that of low (<10%) expressing tumors (p < 0.05). MIB1 immunostaining may have useful prognostic value in ovarian clear cell adenocarcinoma.
Original language | English |
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Pages (from-to) | 315-319 |
Number of pages | 5 |
Journal | International Journal of Gynecological Pathology |
Volume | 15 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1996 |
Keywords
- Clear cell adenocarcinoma
- Immunohistochemistry
- MIB1
- Ovary
- Prognosis
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Obstetrics and Gynaecology