Evaluation with MIB1 antibody of proliferative activity in ovarian clear cell adenocarcinoma

Yutaka Morimura, Kazuhiko Hoshi, Xiang Li Hang, Yoshimasa Takano, Mari Ohishi, Tsuyoshi Honda, Hidekazu Yamada, Akira Sato

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)


    The purpose of this study was to determine whether proliferative activity is a prognostic factor in ovarian clear cell adenocarcinoma. The paraffin-embedded sections from eight cases of ovarian clear cell adenocarcinoma were immunostained with monoclonal antibody MIB1 using microwave oven heating for antigen retrieval. The difference in survival (Kaplan-Meier) between patients with high and low MIB1 expression was estimated with the generalized Wilcoxon test. MIB1 positivity ranged from 1.80 to 27.12% with a mean of 11.43%. A cutoff point of 10% dichotomized patients into two groups. The survival of high (≤10%) expressing tumors was worse than that of low (<10%) expressing tumors (p < 0.05). MIB1 immunostaining may have useful prognostic value in ovarian clear cell adenocarcinoma.

    Original languageEnglish
    Pages (from-to)315-319
    Number of pages5
    JournalInternational Journal of Gynecological Pathology
    Issue number4
    Publication statusPublished - 1996


    • Clear cell adenocarcinoma
    • Immunohistochemistry
    • MIB1
    • Ovary
    • Prognosis

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine
    • Obstetrics and Gynaecology


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