Evaluation of the chronotropic property of captopril in hypertensive patients

Yutaka Imai, Keishi Abe, Makito Sato, Toshiaki Haruyama, Masao Hiwatari, Toshikazu Goto, Ko Sato, Yutaka Kasai, Jiro Tajima, Kaoru Yoshinaga

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9 Citations (Scopus)


Captopril was administered (50 mg orally) to 88 untreated hypertensive patients (70 with essential hypertension, eight with renal arterial disease, 10 with renal parenchymal disease) and to 25 hypertensive patients treated with sympatholytic or β-blocking agent (20 with essential hypertension, five with renal arterial disease). In the former group, captopril caused a decrease in heart rate (HR) in 18 patients and an increase in only two. As a whole, captopril caused significant decrease in blood pressure without increase in HR. Significant negative correlation was observed between change in HR and plasma renin activity obtained before captopril administration (n = 79, r = -0.425, p < 0.0001). Hypotensive and chronotropic effects of captopril were almost identical in untreated and treated patients. Hypotensive effects caused by captopril and nifedipine (20 mg orally) were almost identical. Nifedipine caused reflex tachycardia, while captopril caused slight bradycardia. Absence of compensatory tachycardia appears to be related to reduction of endogenous angiotensin II by captoprill.

Original languageEnglish
Pages (from-to)1339-1345
Number of pages7
JournalAmerican Heart Journal
Issue number6
Publication statusPublished - 1982 Dec
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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