Evaluation of the biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe [18F]FACT in humans

Miho Shidahara, Manabu Tashiro, Nobuyuki Okamura, Shozo Furumoto, Katsutoshi Furukawa, Shoichi Watanuki, Kotaro Hiraoka, Masayasu Miyake, Ren Iwata, Hajime Tamura, Hiroyuki Arai, Yukitsuka Kudo, Kazuhiko Yanai

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Background: The biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe ([18F] FACT) was investigated in humans. Methods: Six healthy subjects (three males and three females) were enrolled in this study. An average of 160.8 MBq of [18F] FACT was intravenously administered, and then a series of whole-body PET scans were performed. Nineteen male and 20 female source organs, and the remainder of the body, were studied to estimate time-integrated activity coefficients. The mean absorbed dose in each target organ and the effective dose were estimated from the time-integrated activity coefficients in the source organs. Biodistribution data from [18F] FACT in mice were also used to estimate absorbed doses and the effective dose in human subjects; this was compared with doses of [18F] FACT estimated from human PET data. Results: The highest mean absorbed doses estimated using human PET data were observed in the gallbladder (333 ± 251 μGy/MBq), liver (77.5 ± 14.5 μGy/MBq), small intestine (33.6 ± 30.7 μGy/MBq), upper large intestine (29.8 ± 15.0 μGy/MBq) and lower large intestine (25.2 ± 12.6 μGy/MBq). The average effective dose estimated from human PET data was 18.6 ± 3.74 μSv/MBq. The highest mean absorbed dose value estimated from the mouse data was observed in the small intestine (38.5 μGy/MBq), liver (25.5 μGy/MBq) and urinary bladder wall (43.1 μGy/MBq). The effective dose estimated from the mouse data was 14.8 μSv/MBq for [18F] FACT. Conclusions: The estimated effective dose from the human PET data indicated that the [18F] FACT PET study was acceptable for clinical purposes.

Original languageEnglish
Article number32
Pages (from-to)1-10
Number of pages10
JournalEJNMMI Research
Volume3
Issue number1
DOIs
Publication statusPublished - 2013

Keywords

  • Amyloid imaging
  • MIRD
  • Positron emission tomography
  • Radiation dosimetry

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Evaluation of the biodistribution and radiation dosimetry of the <sup>18</sup>F-labelled amyloid imaging probe [<sup>18</sup>F]FACT in humans'. Together they form a unique fingerprint.

Cite this