Evaluation of the anti-hyperglycemic effect and safety of microorganism 1-deoxynojirimycin

Soo Takasu, Isabella Supardi Parida, Shinji Onose, Junya Ito, Ryoichi Ikeda, Kenji Yamagishi, Oki Higuchi, Fukuyo Tanaka, Toshiyuki Kimura, Teruo Miyazawa, Kiyotaka Nakagawa

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

1-Deoxynojirimycin (DNJ) is a potent a-glucosidase inhibitor and thus beneficial for prevention of diabetes. While we have succeeded in obtaining the culture supernatant extract (CSE) rich in DNJ from microorganism source, information regarding its anti-hyperglycemic effect and safety were still limited. Therefore, this study was aimed to evaluate the antihyperglycemic effect and safety of microorganism DNJ. Oral sucrose tolerance test was performed, and the result showed that CSE was able to significantly suppress the blood glucose elevation and suggested DNJ as the main active compound. To determine its safety, the absorption and excretion of microorganism DNJ were evaluated using 15N labeling method. Our findings investigated the recovery rate of 15N from DNJ reached 80% up to 48 hours after oral administration, suggesting its rapid excretion, suggesting the safety of DNJ. This study verified the functional properties and safety of DNJ from microorganisms, suggesting its potential use for functional purpose.

Original languageEnglish
Article numbere0199057
JournalPloS one
Volume13
Issue number6
DOIs
Publication statusPublished - 2018 Jun

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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