Evaluation of the ameliorative effects of immunosuppressants on crescentic glomerulonephritis in SCG/Kj mice

Kan Saiga, Minako Yoshida, Iwao Nakamura, Eriko Toyoda, Kazuhiro Tokunaka, Hirohisa Morohashi, Fuminori Abe, Kyuichi Nemoto, Masato Nose

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The therapeutic efficacy of immunosuppressants for treating rapidly progressive glomerulonephritis (RPGN) with crescent formation remains controversial. SCG/Kj mice spontaneously develop RPGN-like symptoms, characteristic of crescentic glomerulonephritis and systemic small vessel vasculitis, associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA). We evaluated the "ameliorative", not prophylactic, effects of immunosuppressive agents, deoxyspergualin (DSG), cyclophosphamide (CYC) and prednisolone (PDN), on RPGN in these mice. DSG at intraperitoneal doses of 3 and 6 mg/kg, CYC at an oral dose of 12 mg/kg, or PDN at an intraperitoneal dose of 120 mg/kg was administered once a day for 21 days to female mice "at the onset of hematuria". A set of control SCG/Kj mice received only saline injections. DSG and CYC significantly prolonged survival, improved the proteinuria, hematuria and hyperuremia, and decreased the serum level of myeloperoxidase-ANCA. Moreover, DSG significantly suppressed the formation of crescents in glomeruli. PDN failed to affect any of the parameters. DSG might be useful for inducing remission in crescentic glomerulonephritis involved in RPGN.

Original languageEnglish
Pages (from-to)1183-1189
Number of pages7
JournalInternational Immunopharmacology
Volume8
Issue number9
DOIs
Publication statusPublished - 2008 Sep

Keywords

  • ANCA
  • Cyclophosphamide
  • Deoxyspergualin
  • Rapidly progressive glomerulonephritis
  • Therapy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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