Evaluation of self-expandable, FK506-coated, covered stents in canine animal model

Sachiko Sato, Yasuhide Nakayama, Toshio Matsuhashi, Kazumasa Seiji, Kenichi Matsunaga, Chiaki Takasawa, Tadashi Ishibashi, Yue Min Zhou, Hatsue Ishibashi-Ueda, Yoshihiro Okamoto, Hiroyuki Asano, Shoki Takahashi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

This study aimed to evaluate whether drug coating of the recently developed covered SENDAI stents-self-expandable stents covered with segmented polyurethane (SPU) films-reduces neointimal thickening in animal model. FK506, which is one of the most effective immunosuppressants, was used. Bare stents; non-coated, covered stents; and FK506-coated, covered stents were placed bilaterally in the external iliac arteries of beagle dogs. After 1-month observation period, angiography did not show significant stent-induced stenosis. Histological evaluation revealed a completely endothelialized intravascular lumen and the absence of thrombus formation. The area of the intimal thickening induced by the FK506-coated stents was significantly smaller than that induced by the non-coated stents, whereas it was larger in the case of both the covered stents than that in the case of the bare stent. In conclusion, FK506 treatment of the self-expandable, covered stents was confirmed to effectively inhibit intimal thickening, although the SPU film used for covering functioned as a drug carrier in addition to a scaffold for intimal formation.

Original languageEnglish
Pages (from-to)647-652
Number of pages6
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume90
Issue number2
DOIs
Publication statusPublished - 2009 Aug

Keywords

  • Covered stent
  • FK506
  • SENDAI stent
  • Segmented polyurethane
  • Self-expandable

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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