Evaluation of peri-implant bone metabolism under immediate loading using high-resolution Na18F-PET

Yutaka Matsuo, Toru Ogawa, Miou Yamamoto, Aya Shibamoto, Juan Ramón Vanegas Sáenz, Masayoshi Yokoyama, Yoshiaki Kanda, Jun Toyohara, Keiichi Sasaki

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: This study aimed to examine the influence of immediate loading on the dynamic changes of bone metabolism around dental implants using a high-resolution semiconductor sodium 18F-fluoride (Na18F)-PET. Methods: Tibiae of 12 adult male rats were divided into 4 groups: immediate loading (IL), no loading (NL), bone defect (BD), and control (CTR). For the IL group, a 4.0-N load was applied continuously by two closed-coil springs attached between two implants in tibia. Each rat received an intravenous injection of Na18F and was scanned by high-resolution Na18F-PET at day 1 and then at weeks 1, 2, 3, 4, 5, 6, and 8 after surgery. Bone metabolism around the implant was evaluated by standardized uptake value (SUV), which indicates the outcome of Na18F accumulation. CT scanning was also performed, and PET and CT images were superposed to determine the anatomical orientation in PET images. Results: Bone metabolism peaked at 7 days after surgery and then gradually decreased in all three test groups (IL, NL, and BD). SUVs of all three test groups were significantly higher than the baseline at 1, 2, 3, and 4 weeks after surgery, with SUVs in the IL group returning to baseline levels earlier than those in the NL and BD groups. Conclusions: Fluorine integrates preferentially with the initial low-calcified bone; thus, our results suggest that immediate loading promotes the calcification of the bone tissue in the early stage on peri-implant bone formation. Clinical relevance: Na18F-PET allows for an estimate of bone metabolism change around the implant.

Original languageEnglish
Pages (from-to)2029-2037
Number of pages9
JournalClinical Oral Investigations
Volume21
Issue number6
DOIs
Publication statusPublished - 2017 Jul 1

Keywords

  • Bone metabolism
  • Immediate loading
  • NaF-PET
  • Peri-implant bone

ASJC Scopus subject areas

  • Dentistry(all)

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