Evaluation of optimal scan time by bootstrap approach for quantitative analysis in PET receptor study

Yoko Ikoma, Miho Shidahara, Hiroshi Ito, Chie Seki, Tetsuya Suhara, Iwao Kanno

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Quantification of the receptor binding potential (BP) in human brain has been performed with positron emission tomography. In this quantitative analysis, the uncertainty in estimated kinetic parameters depends on the SNR. Evaluation of the reliability of parameter estimates is important for the optimization of scan protocol and quantitative analysis methods. However, estimating the reliability is not easy for human data because the true noise level is not precisely known. In this study, we have evaluated a method for estimating the reliability of kinetic parameters with a bootstrap approach for both simulated and human data, and applied this method to evaluating the influence of scan time on the error in BP estimated from PET [11C]raclopride studies. As a result, it was possible to deduce the reliability of kinetic parameter estimates in region-of-interest analysis of human data using the replicated data generated by bootstrap method. In [11C]raclopride studies, the mean estimated BP value did not change when the scan time decreased from 90 to 15 min. However, the uncertainty in BP estimates became larger as the scan time became shorter. With the bootstrap method, it is possible to easily assess the reliability of parameter estimates using only the measured data, and this method can be applied to optimizing scan protocol.

Original languageEnglish
Title of host publication2006 IEEE Nuclear Science Symposium - Conference Record
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2131-2133
Number of pages3
ISBN (Print)1424405610, 9781424405619
DOIs
Publication statusPublished - 2006 Jan 1
Externally publishedYes
Event2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD - San Diego, CA, United States
Duration: 2006 Oct 292006 Nov 4

Publication series

NameIEEE Nuclear Science Symposium Conference Record
Volume4
ISSN (Print)1095-7863

Other

Other2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD
CountryUnited States
CitySan Diego, CA
Period06/10/2906/11/4

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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