TY - JOUR
T1 - Evaluation of IFCC standardization method in alkaline phosphatase (ALP) measurement
AU - Goto, Yoshie
AU - Sasaki, Katsuyuki
AU - Kashio, Kazushi
AU - Yokota, Yurina
AU - Takeda, Takuya
AU - Hiraizumi, Atsuko
AU - Fujimaki, Shin Ichi
AU - Fujiwara, Tohru
N1 - Publisher Copyright:
© 2020 Japanese Journal of Clinical Chemistry. All rights reserved.
PY - 2020
Y1 - 2020
N2 - Japan Society of Clinical Chemistry (JSCC) has decided that JSCC-based reference method to measure alkaline phosphatase (ALP) will be changed to the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)-based method from April 2020, allowing one-year transitional period. By analyzing ALP value based on both JSCC and IFCC method, we evaluated their correlation and the potential discrepancies caused by differential reactivity of specific isozymes, such as placental and intestinal isozymes. When the placental and the intestinal isozymes were excluded for the analysis, we confirmed the high validity of the conversion factor (2.84 times) from IFCC to JSCC method. In this study, we investigated the relationship between the emergence of placental isozyme and gestational weeks. For intestinal isozyme, we evaluated the effect of food intake (outpatients versus inpatient) as well as blood type. These results would provide useful information for all medical staffs.
AB - Japan Society of Clinical Chemistry (JSCC) has decided that JSCC-based reference method to measure alkaline phosphatase (ALP) will be changed to the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)-based method from April 2020, allowing one-year transitional period. By analyzing ALP value based on both JSCC and IFCC method, we evaluated their correlation and the potential discrepancies caused by differential reactivity of specific isozymes, such as placental and intestinal isozymes. When the placental and the intestinal isozymes were excluded for the analysis, we confirmed the high validity of the conversion factor (2.84 times) from IFCC to JSCC method. In this study, we investigated the relationship between the emergence of placental isozyme and gestational weeks. For intestinal isozyme, we evaluated the effect of food intake (outpatients versus inpatient) as well as blood type. These results would provide useful information for all medical staffs.
KW - Alkaline phosphatase(ALP)
KW - Conversion factor
KW - IFCC reference method
KW - Intestinal alkaline phosphatase
KW - Placental alkaline phosphatase
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M3 - Article
AN - SCOPUS:85097674616
SN - 0370-5633
VL - 49
SP - 199
EP - 205
JO - Japanese Journal of Clinical Chemistry
JF - Japanese Journal of Clinical Chemistry
IS - 3
ER -