Evaluation of Compliance of Poly (vinyl alcohol) Hydrogel for Development of Arterial Biomodeling

Hiroyuki Kosukegawa, K. Mamada, K. Kuroki, L. Liu, K. Inoue, Toshiyuki Hayase, Makoto Ohta

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

An in vitro blood vessel biomodeling with realistic mechanical properties and geometrical structures will be helpful for the training of intervention, preoperative simulation, and realizing the same physical conditions of blood flow. Poly (vinyl alcohol) hydrogel (PVA-H) with low surface friction, good transparency, and similar elasticity to blood vessel has been developed and accepted as a good material for biomodeling. However, the compliance of PVA-H vessel model has not been measured. In this study, we changed the elasticity and measured the compliance of a box-typed PVA-H biomodeling, to represent the similar compliance to a real artery. PVA powders were dissolved in a mixture of water and organic solvent so that PVA solutions of 12, 18 wt% were prepared. The model was subjected to hydrostatic pressure by adding distilled water and the inner diameter was measured using an ultrasound system. The compliance of each model was calculated from the strain of inner diameter and the inner pressure. The inner diameter of model increases linearly as the inner pressure increases. The compliance of PVA-H model is constant according to pressure change, while that of a real blood vessel changes nonlinearly. This difference may depend on the isotropic characteristics of PVA-H, whereas a real blood vessel is anisotropic. These results indicate that adding anisotropy, such as orientation of PVA, to model would be necessary to represent the compliance of a real artery.

Original languageEnglish
Title of host publication13th International Conference on Biomedical Engineering - ICBME 2008
Pages1993-1995
Number of pages3
DOIs
Publication statusPublished - 2009 Dec 1
Event13th International Conference on Biomedical Engineering, ICBME 2008 - , Singapore
Duration: 2008 Dec 32008 Dec 6

Publication series

NameIFMBE Proceedings
Volume23
ISSN (Print)1680-0737

Other

Other13th International Conference on Biomedical Engineering, ICBME 2008
Country/TerritorySingapore
Period08/12/308/12/6

Keywords

  • Blood vessel biomodeling
  • Compliance
  • Mechanical property
  • Poly (vinyl alcohol) Hydrogel
  • Ultrasound

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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