Evaluation of apatite-forming ability and antibacterial activity of raw silk fabrics doped with metal ions

Hiroki Chigama, Hiroyasu Kanetaka, Maiko Furuya, Kotone Yokota, Masakazu Kawashita

Research output: Contribution to journalArticlepeer-review


Raw silk can be doped with metal element such as Ca and Zn due to high affinity of sericin, outer layer of the raw silk. Thus, raw silk doped with metal element is expected to show various functions favorable as biomaterials. In this study, we investigated to apatite-forming ability in simulated body fluid (SBF) and antibacterial activity against Escherichia coli of metal-doped raw silk fabric. The samples were prepared by soaking in the aqueous solution containing Ca, Cu or Zn ion. Cu-doped and Zn-doped raw silk fabric showed antibacterial activity, suggesting antibacterial agents of Cu and Zn released from the samples killed the bacteria. On the other hand, Ca-doped raw silk fabric showed both apatite-forming ability and antibacterial activity. The apatite formation on fabric is might be because Ca ion released from the sample increased a degree of supersaturation of SBF to respect with apatite and accelerate the apatite formation. Also, it is considered that release of Ca ion causes pH increase locally and the bacteria hardly survive at the sample surface. Therefore, Ca-doped, Cu-doped and Zn-doped raw silk fabric are useful as antibacterial biomaterials. Further, Ca-doped raw silk fabric has potential to bond to living bone.

Original languageEnglish
Pages (from-to)495-501
Number of pages7
JournalFuntai Oyobi Fummatsu Yakin/Journal of the Japan Society of Powder and Powder Metallurgy
Issue number8
Publication statusPublished - 2018


  • Antibacterial activity
  • Apatite-forming ability
  • Raw silk
  • Sericin

ASJC Scopus subject areas

  • Mechanical Engineering
  • Industrial and Manufacturing Engineering
  • Metals and Alloys
  • Materials Chemistry


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