TY - JOUR
T1 - Evaluation of a newly developed piezo actuator-driven pulsed water jet system for liver resection in a surviving swine animal model
AU - Nakanishi, Chikashi
AU - Nakano, Toru
AU - Nakagawa, Atsuhiro
AU - Sato, Chiaki
AU - Yamada, Masato
AU - Kawagishi, Naoki
AU - Tominaga, Teiji
AU - Ohuchi, Noriaki
N1 - Funding Information:
Atsuhiro Nakagawa and Teiji Tominaga received research support for this study from Seiko EPSON Co., Ltd. under a collaborative contract with Tohoku University, and the piezo actuator-driven pulsed water jet system was donated by Seiko EPSON Co., Ltd. Otherwise, the authors do not have any other conflicts of interest concerning the materials or methods used in this study or the findings reported in this paper.
Funding Information:
This work was supported in part by a Translational Research Network Program, B13 (to Tominaga, Nakagawa, Ohuchi, Nakano, Nakanishi and Yamada); Grants-in-Aid for Scientific Research (C) (Nos. 24591931 and 25670549, to Nakano and Nakagawa) and Challenging Exploratory Research (Nos. 21659313 and 21659334 to Nakagawa, and No. 25670565 to Nakano) from the Japanese Ministry of Education, Culture, Sports, Science, and Technology; Grant A from the Japanese Foundation for Research and Promotion of Endoscopy (2009 to Nakano, 2012 to Nakagawa, 2013 to Yamada); and the Collaborative Research Project of the Institute of Fluid Science, Tohoku University (J13047 to Nakagawa). We appreciate the assistance of Teruko Sueta and Nobuko Hashimoto from the Center for Laboratory Animal Research, Tohoku University; Yasuko Furukawa and Yurika Adachi from the experimental laboratory at the Division of Advanced Surgical Science and Technology, Graduate School of Medicine, Tohoku University; and Yayoi Okano, Asaka Ishigamori, and Eriko Ito from the Department of Neurosurgery, Graduate School of Medicine, Tohoku University, for technical and administrative assistance.
Publisher Copyright:
© 2016 Nakanishi et al.
PY - 2016/1/25
Y1 - 2016/1/25
N2 - Background: Preservation of the hepatic vessels while dividing the parenchyma is key to achieving safe liver resection in a timely manner. In this study, we assessed the feasibility of a newly developed, piezo actuator-driven pulsed water jet (ADPJ) for liver resection in a surviving swine model. Methods: Ten domestic pigs underwent liver resection. Parenchymal transection and vessel skeletonization were performed using the ADPJ (group A, n=5) or an ultrasonic aspirator (group U, n=5). The water jet was applied at a frequency of 400Hz and a driving voltage of 80V. Physiological saline was supplied at a flow rate of 7ml/min. After 7days, the animals were killed and their short-term complications were examined and compared between the two groups. Results: No significant complications, such as massive bleeding, occurred in either group during the surgical procedures. The transection time per transection area was significantly shorter in group A than in group U (1.5±0.3 vs. 2.3±0.5min/cm2, respectively, P=0.03). Blood loss per transection area was not significantly different between groups A and U (9.3±4.2 vs. 11.7±2.3ml/cm2, P=0.6). All pigs in group A survived for 7days. No postoperative bleeding or bile leakage was observed in any animal at necropsy. Conclusion: The present results suggested that the ADPJ reduces transection time without increasing blood loss. ADPJ is a safe and feasible device for liver parenchymal transection.
AB - Background: Preservation of the hepatic vessels while dividing the parenchyma is key to achieving safe liver resection in a timely manner. In this study, we assessed the feasibility of a newly developed, piezo actuator-driven pulsed water jet (ADPJ) for liver resection in a surviving swine model. Methods: Ten domestic pigs underwent liver resection. Parenchymal transection and vessel skeletonization were performed using the ADPJ (group A, n=5) or an ultrasonic aspirator (group U, n=5). The water jet was applied at a frequency of 400Hz and a driving voltage of 80V. Physiological saline was supplied at a flow rate of 7ml/min. After 7days, the animals were killed and their short-term complications were examined and compared between the two groups. Results: No significant complications, such as massive bleeding, occurred in either group during the surgical procedures. The transection time per transection area was significantly shorter in group A than in group U (1.5±0.3 vs. 2.3±0.5min/cm2, respectively, P=0.03). Blood loss per transection area was not significantly different between groups A and U (9.3±4.2 vs. 11.7±2.3ml/cm2, P=0.6). All pigs in group A survived for 7days. No postoperative bleeding or bile leakage was observed in any animal at necropsy. Conclusion: The present results suggested that the ADPJ reduces transection time without increasing blood loss. ADPJ is a safe and feasible device for liver parenchymal transection.
KW - Blood loss
KW - Liver resection
KW - Pulsed water jet
KW - Transection time
KW - Ultrasonic aspirator
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U2 - 10.1186/s12938-016-0126-9
DO - 10.1186/s12938-016-0126-9
M3 - Article
C2 - 26809992
AN - SCOPUS:84955294002
VL - 15
JO - BioMedical Engineering Online
JF - BioMedical Engineering Online
SN - 1475-925X
IS - 1
M1 - 9
ER -