Evaluation of a newly developed piezo actuator-driven pulsed water jet system for liver resection in a surviving swine animal model

Chikashi Nakanishi, Toru Nakano, Atsuhiro Nakagawa, Chiaki Sato, Masato Yamada, Naoki Kawagishi, Teiji Tominaga, Noriaki Ohuchi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Background: Preservation of the hepatic vessels while dividing the parenchyma is key to achieving safe liver resection in a timely manner. In this study, we assessed the feasibility of a newly developed, piezo actuator-driven pulsed water jet (ADPJ) for liver resection in a surviving swine model. Methods: Ten domestic pigs underwent liver resection. Parenchymal transection and vessel skeletonization were performed using the ADPJ (group A, n=5) or an ultrasonic aspirator (group U, n=5). The water jet was applied at a frequency of 400Hz and a driving voltage of 80V. Physiological saline was supplied at a flow rate of 7ml/min. After 7days, the animals were killed and their short-term complications were examined and compared between the two groups. Results: No significant complications, such as massive bleeding, occurred in either group during the surgical procedures. The transection time per transection area was significantly shorter in group A than in group U (1.5±0.3 vs. 2.3±0.5min/cm2, respectively, P=0.03). Blood loss per transection area was not significantly different between groups A and U (9.3±4.2 vs. 11.7±2.3ml/cm2, P=0.6). All pigs in group A survived for 7days. No postoperative bleeding or bile leakage was observed in any animal at necropsy. Conclusion: The present results suggested that the ADPJ reduces transection time without increasing blood loss. ADPJ is a safe and feasible device for liver parenchymal transection.

Original languageEnglish
Article number9
JournalBioMedical Engineering Online
Issue number1
Publication statusPublished - 2016 Jan 25


  • Blood loss
  • Liver resection
  • Pulsed water jet
  • Transection time
  • Ultrasonic aspirator

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biomaterials
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging


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