Ethnic difference of Helicobacter pylori gastritis: Korean and Japanese gastritis is characterized by male- and antrum-predominant acute foveolitis in comparison with American gastritis

Inchul Lee, Hojung Lee, Mijung Kim, Manabu Fukumoto, Shinji Sawada, Shriram Jakate, Victor E. Gould

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Aim: To invesrigate the clinicopathological factors underlying the ethnic differences of Helicobacter-pylori gastritis and cancer. Methods: We analyzed clinicopathological parameters of gastric biopsies having H pylori infection that were randomly selected from different ethnic populations including 147 Americans, 149 Japanese, and 181 Koreans. Results: Males were predominant in Japanese and Korean populations (77.9 and 67.4% respectively) in comparison with Americans (48.3%) (P<0.001). H pylori gastritis in Koreans and Japanese was characterized by the predominant antral involvement. In the antrum, neutrophilic infiltration into the proliferative zone of pit, i.e. acute foveolitis, was more frequent in Koreans (82%) than in Japanese (71%) (P<0.05) and Americans (61%) (P<0.001). Interstitial neutrophilic infiltration, intestinal metaplasia and atrophy were also frequent in Koreans and Japanese. In the body, the prevalence of acute foveolitis was not significantly different among the populations while chronic interstitial inflammation and lymphoid follicles were more pronounced in the body of Americans than in the body of others (P<0.01). Conclusion: The male-, and antrum-predominant H pylori gastritis in Koreans and Japanese is compatible with the pattern of sex and topographical distribution of gastric cancer incidence. Our data suggest that persistent acute foveolitis at the proliferative zone is a crucial step in the gastric carcinogenesis.

Original languageEnglish
Pages (from-to)94-98
Number of pages5
JournalWorld Journal of Gastroenterology
Volume11
Issue number1
DOIs
Publication statusPublished - 2005 Jan 7
Externally publishedYes

Keywords

  • Ethnic groups
  • Gastritis
  • Helicobacter pylori infection

ASJC Scopus subject areas

  • Gastroenterology

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