Ethanol-induced developmental neurodegeneration in secretin receptor-deficient mice

Dong Woo Hwang, Bennet Givens, Ichiko Nishijima

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Alcohol exposure during brain development induces neuronal cell death in the brain. Several neuroactive peptides have been shown to protect against alcohol-induced cell death. Secretin is a peptide hormone, and the secretin receptor is expressed in the gut and the brain. To explore a potential role of secretin signal against ethanol neurotoxicity during brain development, secretin receptor-deficient mice were exposed to ethanol on postnatal day 4. We identified significant ethanol-induced apoptosis in the external granular layer of the secretin receptor-deficient cerebellum and in the striatum after ethanol treatment. During the early postnatal period, there is a proliferation of granular cell progenitors that reside in the external granular layer. The results suggest that secretin signal plays a neuroprotective role of neuronal progenitor cells against the neurotoxicity of ethanol.

Original languageEnglish
Pages (from-to)698-701
Number of pages4
JournalNeuroReport
Volume20
Issue number7
DOIs
Publication statusPublished - 2009 May 6
Externally publishedYes

Keywords

  • Cerebellum
  • Developing brain
  • External granular layer
  • Fetal alcohol syndrome
  • Secretin
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)

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