Ethanol-free antisolvent crystallization of glycine by liquefied dimethyl ether

Hideki Kanda, Tsubasa Katsube, Rintaro Hoshino, Mitsuhiro Kishino, Wahyudiono, Motonobu Goto

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Liquefied dimethyl ether (DME) was employed as an antisolvent to crystallize glycine from its aqueous solution. The proposed method can be performed at 20–25 °C and has the potential to reduce the energy consumption of drying or crystallizing using ethanol. α-Glycine crystals were successfully obtained from glycine aqueous solutions by mixing in liquefied DME, which was easily removed from the crystals by decompression. Contact with a liquefied DME/water mixture and small γ-glycine crystals resulted in the α-glycine converting to γ-glycine. This was only observed for saturated glycine solutions. We speculated that this conversion occurs via a solution-mediated transition. Pure liquefied DME is not capable of promoting solvent-mediated transitions, so saturated glycine solutions treated with the pure antisolvent can give α-glycine as the sole product. Food science, Chemical engineering, Materials, Chemistry, Natural product, Amino acid, Crystallization, Antisolvent, Subcritical fluid.

Original languageEnglish
Article numbere05258
Issue number10
Publication statusPublished - 2020 Oct
Externally publishedYes


  • Amino acid
  • Antisolvent
  • Chemical engineering
  • Chemistry
  • Crystallization
  • Food science
  • Materials
  • Natural product
  • Subcritical fluid

ASJC Scopus subject areas

  • General


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