Estimation of 99mTc-GSA receptor amount by non-linear 3-compartment model: Ligand-receptor binding model without blood sampling

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Abstract

99mTc-GSA (galactosyl serum albumin) receptor amount (Ro) was estimated by a non-linear 3-compartment model of the ligand-receptor binding without blood sampling. Forward/reverse rate constants and receptor amount were assumed to be variable. Relationship between this parameter and other conventional parameters including 1CG R 15 (15-minutes retention rate of indocyanine green) was evaluated for 43 surgical candidates with liver tumors. Linear relationships between Ro and HH 15 and LHL 15 were R 2 =0.73 and 0.72, respectively. Linear relationship between Ro and R(max), the maximum removal rate, is also good (R 2=0.84), and the regression line (y =0.038x + 0.066) was slightly over 0 at y-interception. Linear relationship between Ro and ICG R 15, was poor (R 2 = 0.39) and relationship was rather a concave shape. Linear relationship of reduction rate between Ro and non-tumor tissue volume of the liver, which assessed at the same day of two weeks after the operation, was y = 1.09x - 0.01 (R 2=0.82). GSA receptor amount, Ro, seems to change proportional to non-tumor liver tissue volume changing before and after hepatectomy. Complementary to 1CG R 15, it may be an useful and intuitive parameter for hepatectomy.

Original languageEnglish
Pages (from-to)753-760
Number of pages8
JournalKakuigaku
Volume36
Issue number7
Publication statusPublished - 1999 Nov 11
Externally publishedYes

Keywords

  • Asialoglycoprotein receptor
  • Multicompartment model
  • Non- linear binding
  • Tc-GSA

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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