TY - JOUR
T1 - Estimation of serum tumour necrosis factor-α and correlation to tumour markers in patients with oral squamous cell carcinoma
AU - Kurokawa, Hideo
AU - Takeda, Shinobu
AU - Yamashita, Yoshihiro
AU - Nakamura, Takashi
AU - Murata, Tomoyuki
AU - Takahashi, Tetsu
AU - Fukuyama, Hiroshi
AU - Zhang, Min
AU - Ishibashi, Hiroaki
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Objectives: Estimation of serum tumour necrosis factor-α levels and correlation with tumour markers for the prognosis of oral squamous cell carcinoma before treatment. Patients and Methods: Serum levels of tumour necrosis factor-α and 3 other tumour markers - carcinoembryonic antigen, squamous cell carcinoma antigen, and immunosuppressive acidic protein -were simultaneously measured in 38 patients with oral squamous cell carcinoma and in 36 healthy controls. Results: The mean serum concentration of tumour necrosis factor-α for patients with oral squamous cell carcinoma (14.1 ± 13.2 pg/mL) was significantly higher than that of healthy controls (5.2 ± 3.1 pg/mL) [p < 0.05]. The mean serum concentration of tumour necrosis factor-α was lower for patients who were pathological node-positive than for pathological node-negative patients. A significant correlation was observed between the serum tumour necrosis factor-α levels and pathological parameters. The mean serum concentration of tumour necrosis factor-α was also significantly higher for patients who had a good clinical course (16.7 ± 18.6 pg/mL) than for those with a poor clinical course (9.6 ± 5.9 pg/mL) [p < 0.05]. The survival curve revealed a better prognosis for serum tumour necrosis factor-α-positive patients than for serum tumour necrosis factor-α-negative patients. A significant correlation was observed between the serum tumour necrosis factor-α levels and the tumour markers, squamous cell carcinoma antigen and immunosuppressive acidic protein (p < 0.05). Conclusion: An evaluation of serum tumour necrosis factor-α level in patients with oral squamous cell carcinoma appears to be a valuable screening tool for the prognosis and treatment of patients with this cancer.
AB - Objectives: Estimation of serum tumour necrosis factor-α levels and correlation with tumour markers for the prognosis of oral squamous cell carcinoma before treatment. Patients and Methods: Serum levels of tumour necrosis factor-α and 3 other tumour markers - carcinoembryonic antigen, squamous cell carcinoma antigen, and immunosuppressive acidic protein -were simultaneously measured in 38 patients with oral squamous cell carcinoma and in 36 healthy controls. Results: The mean serum concentration of tumour necrosis factor-α for patients with oral squamous cell carcinoma (14.1 ± 13.2 pg/mL) was significantly higher than that of healthy controls (5.2 ± 3.1 pg/mL) [p < 0.05]. The mean serum concentration of tumour necrosis factor-α was lower for patients who were pathological node-positive than for pathological node-negative patients. A significant correlation was observed between the serum tumour necrosis factor-α levels and pathological parameters. The mean serum concentration of tumour necrosis factor-α was also significantly higher for patients who had a good clinical course (16.7 ± 18.6 pg/mL) than for those with a poor clinical course (9.6 ± 5.9 pg/mL) [p < 0.05]. The survival curve revealed a better prognosis for serum tumour necrosis factor-α-positive patients than for serum tumour necrosis factor-α-negative patients. A significant correlation was observed between the serum tumour necrosis factor-α levels and the tumour markers, squamous cell carcinoma antigen and immunosuppressive acidic protein (p < 0.05). Conclusion: An evaluation of serum tumour necrosis factor-α level in patients with oral squamous cell carcinoma appears to be a valuable screening tool for the prognosis and treatment of patients with this cancer.
KW - Biological
KW - Carcinoma
KW - Prognosis
KW - Squamous cell
KW - Tumour markers
KW - Tumour necrosis factors
UR - http://www.scopus.com/inward/record.url?scp=0036402878&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036402878&partnerID=8YFLogxK
U2 - 10.1016/S0915-6992(02)80036-X
DO - 10.1016/S0915-6992(02)80036-X
M3 - Article
AN - SCOPUS:0036402878
VL - 14
SP - 148
EP - 154
JO - Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
JF - Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
SN - 2212-5558
IS - 3
ER -