Estimation of polychlorinated biphenyls intake through fish oil-derived dietary supplements and prescription drugs in the Japanese population

Y. Matsuo, K. Nakai, I. Sakuma, K. Akutsu, N. Tatsuta, M. Ishiyama, T. Higuchi, N. Ryuda, D. Ueno

Research output: Contribution to journalArticle

Abstract

Background: Oily fish and their extracted oils may be a source of polychlorinated biphenyls (PCBs) which can induce toxic effects on the consumers. The main aim of this survey was estimation of PCBs intake through fish oil-derived dietary supplements and prescription drugs in the Japanese population. Methods: PCBs levels were determined in 20 fish oil-derived dietary supplements and 6 oil-derived prescription drugs from the Japanese market using Gas Chromatography-Mass Spectrometry. Then, the daily exposure to PCBs was estimated. Data were statistically analyzed using JMP software suite. Results: Totally, 17 of the 26 fish oil-derived products were contaminated with PCBs. The median PCB concentrations in the total set of fish oil-derived products was 2.2 ng/g oil wt. with a range of <MDL-720 ng/g oil wt. The average total daily intake of PCBs was estimated to be ranged from 770 to 2800 ng/day in the Japanese population. Conclusion: PCBs intakes through fish oil-derived dietary supplements and prescription drugs in the Japanese adults were much lower than tolerable daily intake.

Original languageEnglish
Pages (from-to)146-152
Number of pages7
JournalJournal of Food Quality and Hazards Control
Volume6
Issue number4
DOIs
Publication statusPublished - 2019 Dec 1

Keywords

  • Dietary supplements
  • Fish oils
  • Japan
  • Polychlorinated biphenyls
  • Prescription drugs
  • Risk assessment

ASJC Scopus subject areas

  • Food Science

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