Estimation of physiological sources of nonlinearity in blood oxygenation level-dependent contrast signals

Daehun Kang, Yul Wan Sung, Satoshi Shioiri

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Blood oxygenation level-dependent (BOLD) contrast appears through a variation in the transverse relaxation rate of magnetic resonance signals induced by neurovascular coupling and is known to have nonlinear characteristics along echo time (TE) due to the intra-vasculature. However, the physiological causes of this nonlinearity are unclear. We attempted to estimate the physiological information related to the nonlinearity of BOLD signals by using a two-compartment model. For this purpose, we used a multi-echo gradient-echo echo-planar imaging sequence and developed a computational method to estimate the physiological information from the TE-dependent BOLD signals. The results showed that the average chemical exchange time in the intra-vasculature varied during stimulation, which might be the essential source of the nonlinearity.

Original languageEnglish
Pages (from-to)121-129
Number of pages9
JournalMagnetic Resonance Imaging
Volume46
DOIs
Publication statusPublished - 2018 Feb

Keywords

  • BOLD signal
  • Chemical exchange
  • Gradient-echo
  • Multi-echo
  • Nonlinearity
  • TE-dependence

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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