Estimation of non-uniform membrane property over the dendrite: Data assimilation approach using bioimaging data and multi-compartment model

Toshiaki Omori, Toru Aonishi, Hiroyoshi Miyakawa, Masashi Inoue, Masato Okada

Research output: Contribution to conferencePaperpeer-review

Abstract

The information processing in individual neurons is highly dependent on the non-uniform distribution of membrane property over the dendrite. However, this non-uniform distribution is unknown, since its direct measurement at the distal dendrite is difficult with present techniques. In the present study, we extract this important but hidden feature of the dendrite by "data assimilation method"; the non-distribution of the membrane property over the dendrite is estimated by using simulations with a morphologically detailed-compartment model and bioimaging data from the hippocampus. The estimated distribution is shown to be a steep sigmoid function, surprisingly suggesting that the spatial segregation of the membrane property corresponds to that of synaptic inputs to the hippocampal CA1 pyramidal neuron.

Original languageEnglish
Publication statusPublished - 2009 Jan 1
EventAsia Simulation Conference 2009, JSST 2009 - Shiga, Japan
Duration: 2009 Oct 72009 Oct 9

Other

OtherAsia Simulation Conference 2009, JSST 2009
CountryJapan
CityShiga
Period09/10/709/10/9

Keywords

  • Dendrite
  • EPSP propagation
  • Extracellular electric field
  • Hippocampal CA1 pyramidal neurons
  • Membrane resistance
  • Multi-compartment model

ASJC Scopus subject areas

  • Modelling and Simulation

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