Estimation of maximum ventricular elastance under assistance with a rotary blood pump

Telma K. Sugai, Akira Tanaka, Makoto Yoshizawa, Yasuyuki Shiraishi, Tomoyuki Yambe, Shin Ichi Nitta, Atsushi Baba

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The maximum ventricular elastance is a reliable index for assessing the cardiac function from changes in its pressure-volume relationship. The advantage of this index is that it can represent the contractility of either unassisted hearts or native hearts assisted with rotary blood pumps. However, there are situations in which changes in the ventricular load required for the conventional estimation method might be risky. For example, in a bridge-to-recovery the cardiac function should also be continuously observed after the implantation of a rotary blood pump. In this article, we present the results of the estimation of the maximum elastance with in vivo data using the parameter optimization method, which is a single-beat estimation method. The estimated values for the normal cardiac function (6.8 ± 0.6, 4.5 ± 0.9, 4.2 ± 1.8 mm Hg/mL) were significantly different from those for the low cardiac function (3.2 ± 1.5, 1.9 ± 1.0, 1.9 ± 1.2 mm Hg/mL) from the data of the three animals that were analyzed. Besides, the maximum elastance values were independent of the pump rotational speed. These results indicate that this index might be useful for the detection of the myocardial recovery.

Original languageEnglish
Pages (from-to)442-446
Number of pages5
JournalArtificial Organs
Volume34
Issue number5
DOIs
Publication statusPublished - 2010 May

Keywords

  • Elastance
  • Estimation techniques
  • Heart contractility
  • Myocardial recovery
  • Ventricular assist device
  • Ventricular function

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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