Estimation of intracellular calcium ion concentration by nonlinear state space modeling

Takamasa Tsunoda, Toshiaki Omori, Hiroyoshi Miyakawa, Masato Okada, Toru Aonishi

Research output: Contribution to conferencePaperpeer-review

Abstract

Calcium imaging method has superior ability in recording of spatial-temporal variations of ion concentrations. However, it has two major problems. First, the imaging signals are too noisy. Second, the observation data are the fluorescent intensities of Ca2+ indicator dyes that are only indirect information about the Ca2+ concentration. We made a nonlinear state-space model for Ca imaging series involving Ca2+ kinetics and a noisy fluorescent intensity pickup process. We devised a recursive update algorithm for estimating the Ca2+ concentration and Ca influx and gave the EM algorithm for inferring model parameters.

Original languageEnglish
Publication statusPublished - 2009 Jan 1
EventAsia Simulation Conference 2009, JSST 2009 - Shiga, Japan
Duration: 2009 Oct 72009 Oct 9

Other

OtherAsia Simulation Conference 2009, JSST 2009
CountryJapan
CityShiga
Period09/10/709/10/9

Keywords

  • Ca imaging
  • Nonlinear state-space model

ASJC Scopus subject areas

  • Modelling and Simulation

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