Abstract
Calcium imaging method has superior ability in recording of spatial-temporal variations of ion concentrations. However, it has two major problems. First, the imaging signals are too noisy. Second, the observation data are the fluorescent intensities of Ca2+ indicator dyes that are only indirect information about the Ca2+ concentration. We made a nonlinear state-space model for Ca imaging series involving Ca2+ kinetics and a noisy fluorescent intensity pickup process. We devised a recursive update algorithm for estimating the Ca2+ concentration and Ca influx and gave the EM algorithm for inferring model parameters.
| Original language | English |
|---|---|
| Publication status | Published - 2009 Jan 1 |
| Event | Asia Simulation Conference 2009, JSST 2009 - Shiga, Japan Duration: 2009 Oct 7 → 2009 Oct 9 |
Other
| Other | Asia Simulation Conference 2009, JSST 2009 |
|---|---|
| Country | Japan |
| City | Shiga |
| Period | 09/10/7 → 09/10/9 |
Keywords
- Ca imaging
- Nonlinear state-space model
ASJC Scopus subject areas
- Modelling and Simulation
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Tsunoda, T., Omori, T., Miyakawa, H., Okada, M., & Aonishi, T. (2009). Estimation of intracellular calcium ion concentration by nonlinear state space modeling. Paper presented at Asia Simulation Conference 2009, JSST 2009, Shiga, Japan.