Estimation of age from sclerotic glomeruli

Naoki Fukuda, Yoichi Suzuki, Kaoru Sato, Daisuke Yajima, Mutsumi Hayakawa, Hisako Motani, Kazuhiro Kobayashi, Katsura Otsuka, Sayaka Nagasawa, Hirotaro Iwase

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Glomerular sclerosis is one of the age-related causes of nephron damage. Histological studies of cadaver kidneys in several ethnic groups have shown that there is a consistent relationship between the percentage of sclerotic glomeruli (PSG) and age. However, no study regarding this relationship in the Japanese population has been reported to date. Here, we investigated such relationship in 150 Japanese cadavers that were selected regardless of clinical history. The straight line regression was estimated as follows: Age=23.3+1.36×APSG (APSG: arcsine-transformed PSG). The R2 value of the regression line was 0.598.The diagnostic test with the PSG value (cutoff = 0.6%) for the age stratum (cutoff = 33 years old) showed very high sensitivity (100%) and specificity (97.6%). From the results, PSG appears to be useful for the estimation of a cadaver's age in the Japanese population.

Original languageEnglish
Pages (from-to)123.e1-123.e4
JournalForensic Science International
Volume197
Issue number1-3
DOIs
Publication statusPublished - 2010 Apr

Keywords

  • Age estimation
  • Forensic pathology
  • Sclerotic glomeruli
  • Statistical analysis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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