Estimated distribution of specific membrane resistance in hippocampal CA1 pyramidal neuron

Toshiaki Omori, Toru Aonishi, Hiroyoshi Miyakawa, Masashi Inoue, Masato Okada

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

It has been suggested that dendritic membrane properties play an important role in a synaptic integration. In particular, the specific membrane resistance, one of membrane properties, has been reported to be non-uniformly distributed in a single neuron, although the spatial distribution of the specific membrane resistance is still unclear. To reveal its non-uniformity in dendrite, we estimated the spatial distribution of specific membrane resistance in a single neuron, based on voltage imaging data, observed optically in hippocampal CA1 slices. As the optically recorded data, we used bi-directional propagations of subthreshold excitatory postsynaptic potentials in dendrite, which were not be reproduced numerically with uniform-specific membrane resistance. By numerical simulations for multi-compartment models with non-uniformity of specific membrane resistance, we estimated that the distribution obeys a step function; the optically recorded data were consistently reproduced for the distribution with a steep decrease in the specific membrane resistance at the distal apical dendrite, which occurs 300-500 μm away from the soma. In the estimated distribution, the specific membrane resistance at the distal side is less than about 103 Ωcm2, whereas the resistance at the proximal side is greater than about 104 Ωcm2. This result implies that the specific membrane resistance decreases drastically at the distal apical dendrite in hippocampal CA1 pyramidal neuron.

Original languageEnglish
Pages (from-to)199-208
Number of pages10
JournalBrain research
Volume1125
Issue number1
DOIs
Publication statusPublished - 2006 Dec 13

Keywords

  • Dendrite
  • Multi-compartment model
  • Passive membrane properties
  • Single neuron
  • Synaptic integration

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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