Establishment of Five Human Malignant Non-T Lymphoid Cell Lines and Mixed Lymphocyte-Tumor Reaction

Masayoshi Minegishi, Shigeru Tsuchiya, Naoko Minegishi, Tasuke Konno

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Five human malignant non-T lymphoid cell lines have been established. THP-4 and THP-7 were derived from two children with common type acute lymphoblastic leukemia (ALL), THP-6 and THP-8 from two children with null cell type ALL and THP-9 from a child with malignant lymphoma. THP-4 was positive for cytoplasmic μ, B4, common ALL antigen (CALLA) and Ia-like antigen (Ia), THP-7 positive for B4, CALLA and Ia, THP-8 positive for B4 and Ia, and THP-9 positive for surface μ-λ, Bl, B4, CALLA and Ia. No antigenic determinants for monoclonal antibodies used were detected on THP-6. THP-4, THP-7, THP-8 and THP-9 were able to stimulate allogeneic lymphocytes vigorously. THP-6 without Ia stimulated not only allogeneic lymphocytes, but also autologous ones. THP-7 did not stimulate autologous lymphocytes.

Original languageEnglish
Pages (from-to)283-292
Number of pages10
Journalthe tohoku journal of experimental medicine
Volume151
Issue number3
DOIs
Publication statusPublished - 1987

Keywords

  • B cell differentiation
  • mixed lymphocyte-tumor reaction
  • non-T cell lines

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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