Essential Binding of LukF of Staphylococcal γ-hemolysin Followed by the Binding of hγII for the Hemolysis of Human Erythrocytes

Toshiko Ozawa, Jun Kaneko, Yoshiyuki Kamio

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Staphylococcal γ-hemolysin consists of two protein components, LukF and HγII. This report clarifies the order of binding of the two components to human erythrocytes for the hemolytic activity of the toxin. The initial binding of LukF to the human erythrocytes is essential for the subsequent binding of HγII to the same cells, with the formation of a heat-undissociable protein of about 100 kDa containing LukF and HγII.

Original languageEnglish
Pages (from-to)1181-1183
Number of pages3
JournalBioscience, Biotechnology, and Biochemistry
Volume59
Issue number6
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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