Staphylococcal γ-hemolysin consists of two protein components, LukF and HγII. This report clarifies the order of binding of the two components to human erythrocytes for the hemolytic activity of the toxin. The initial binding of LukF to the human erythrocytes is essential for the subsequent binding of HγII to the same cells, with the formation of a heat-undissociable protein of about 100 kDa containing LukF and HγII.
ASJC Scopus subject areas
- Analytical Chemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry