Erythromycin inhibits Cl- secretion across human nasal gland cells

M. Furukawa, K. Ikeda, T. Oshima, N. Tanno, T. Takasaka

Research output: Contribution to journalArticlepeer-review

Abstract

To study the regulation of ion transport by the human nasal gland (HNG) cells, we developed a system for culturing HNG cells isolated by enzymatic digestion from human nasal polyps. Erythromycin inhibited acetylcholine-induced Cl- secretion in human nasal gland cells. On the other hand, erythromycin had no effect on ATP-induced Cl- secretion in human nasal epithelial cells. Thus, erythromycin might have the effect of reducing nasal secretion in chronic sinusitis.

Original languageEnglish
Pages (from-to)20-22
Number of pages3
JournalOto-Rhino-Laryngology Tokyo
Volume39
Issue number2 SUPPL. 1
Publication statusPublished - 1996 Jan 1

Keywords

  • Cl secretion
  • erythromycin
  • nasal gland cells

ASJC Scopus subject areas

  • Otorhinolaryngology

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