Erythromycin attenuates MUC5AC synthesis and secretion in cultured human tracheal cells infected with RV14

Daisuke Inoue, Hiroshi Kubo, Takahiko Sasaki, Hiroyasu Yasuda, Muneo Numasaki, Hidetada Sasaki, Mutsuo Yamaya

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background and objective: The common cold is a major cause of asthma exacerbation and chronic obstructive lung disease. Rhinovirus is reported to be responsible for more than 50% of cases of the common cold. In a previous study, we reported that rhinovirus infection of cultured airway cells induced MUC5AC mucin overproduction and hypersecretion by activating the p44/42 mitogen-activated protein kinase (p44/42 MAPK) pathway. The aim of this study was to examine the effect of erythromycin on RV14-induced airway mucin overproduction and hypersecretion. Methods: RV14-infected human tracheal epithelial cells were treated with erythromycin. Results: Erythromycin blocked RV14-induced MUC5AC protein overproduction and hypersecretion, and also blocked RV14-induced p44/42 MAPK activation in the cells. Conclusions: Erythromycin may attenuate RV14-induced MUC5AC overproduction and hypersecretion by blocking the p44/42 MAPK pathway or its upstream regulators.

Original languageEnglish
Pages (from-to)215-220
Number of pages6
JournalRespirology
Volume13
Issue number2
DOIs
Publication statusPublished - 2008 Mar 1

Keywords

  • Asthma
  • Erythromycin
  • Mucin
  • Rhinovirus
  • p44/42 MAPK

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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