ERK MAP kinase in G1 cell cycle progression and cancer

Satoru Torii, Takuya Yamamoto, Yoshiki Tsuchiya, Eisuke Nishida

    Research output: Contribution to journalReview articlepeer-review

    191 Citations (Scopus)


    The extracellular-signal-regulated kinase (ERK) mitogen-activated protein (MAP) kinase signaling pathway plays an important role in various cellular responses, including cell proliferation, cell differentiation and cell survival. Recent studies have identified a number of Ras/ERK signaling-related proteins, such as scaffold proteins and inhibitors. These proteins modulate ERK signaling and thereby could give variations in ERK signaling outputs that regulate cell fate decisions. Here we focus on the role of ERK signaling in cell cycle progression from G0/G1 to S phase and cancer.

    Original languageEnglish
    Pages (from-to)697-702
    Number of pages6
    JournalCancer science
    Issue number8
    Publication statusPublished - 2006 Aug 1

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research


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