Eradication of hepatitis C virus could improve immunological status and pyoderma gangrenosum-like lesions

Yasuteru Kondo, Tomoaki Iwata, Takahiro Haga, Osamu Kimura, Masashi Ninomiya, Eiji Kakazu, Takayuki Kogure, Tatsuki Morosawa, Setsuya Aiba, Tooru Shimosegawa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Hepatitis C virus (HCV) can affect immune cells and induce various kinds of immune-related diseases including pyoderma gangrenosum. We experienced a difficult-to-treat case of pyoderma gangrenosum-like lesions in a patient with HCV infection. The patient was treated with pegylated interferon (PEG IFN)-α-2b and ribavirin (RBV) therapy and achieved a sustained virological response. Before the eradication of HCV, the frequency of T-helper 17 cells was remarkably high in comparison to chronic hepatitis C patients without extrahepatic immune-related diseases. Moreover, we could detect negative and positive strand-specific HCV RNA in the CD19+ B lymphocytes and CD4+ T lymphocytes. However, after the eradication of HCV, the immunological status became normal and the pyoderma gangrenosum-like lesions became stable without immunosuppressive therapy. Here, we report a sequential immunological analysis during PEG IFN/RBV therapy and the beneficial effect of HCV eradication in difficult-to-treat pyoderma gangrenosum-like lesions.

Original languageEnglish
Pages (from-to)238-245
Number of pages8
JournalHepatology Research
Volume44
Issue number2
DOIs
Publication statusPublished - 2014 Feb

Keywords

  • CD19
  • CD4
  • Extrahepatic diseases
  • Hepatitis C virus
  • T-helper 17

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases

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